Experimental Zebrafish Models of Mitochondrial Dysfunction in the Pathogenesis of CNS Diseases

被引：2

作者：

Yushko, L. V. ^{[1
]}

Kotova, M. M. ^{[1
]}

Vyunova, T. V. ^{[2
]}

Kalueff, A. V. ^{[1
,3
,4
,5
,6
]}

机构：

[1] Sirius Univ Sci & Technol, Sirius, Fed Territory S, Russia

[2] Life Improvement Future Technol LIFT Ctr, Moscow, Russia

[3] Minist Hlth Russian Federat, Almazov Natl Med Res Ctr, World class Sci Res Ctr Ctr Personalized Med, St Petersburg, Russia

[4] St Petersburg State Univ, Inst Translat Biomed, St Petersburg, Russia

[5] Minist Hlth Russian Federat, Granov Sci Res Ctr Radiol & Surg Technol, Preclin Bioscreening Grp, St Petersburg, Russia

[6] Sci Res Inst Neurosci & Med, Lab Translat Biopsychiatry, Novosibirsk, Russia

来源：

JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY | 2023年 / 59卷 / 06期

关键词：

mitochondria; mitochondrial dysfunction; CNS diseases; model organisms; zebrafish; PARKINSONS-DISEASE; OXIDATIVE STRESS; MOUSE MODEL; MICE; FEATURES; THERAPY; HYPOXIA; GENOME;

D O I：

10.1134/S0022093023060170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial dysfunctions are associated with pathogenesis of various brain disorders, including Alzheimer's, Parkinson's and Huntington's diseases, amyotrophic lateral sclerosis, Leigh syndrome, and autism spectrum disorder. For studying mitochondrial dysfunction, as well as developing and testing new therapeutic strategies, in vivo studies on zebrafish (Danio rerio) are of particular interest due to their biological characteristics, practical laboratory maintenance, and high throughput. Here, we address genetic and pharmacological models of common mitochondrial dysfunctions and related neurological disorders in rodents and zebrafish, focusing of the growing utility of these fish in modeling mitochondrial pathogenesis of various CNS diseases.

引用

页码：2114 / 2128

页数：15

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