Neonatal multisystem inflammatory syndrome during acute SARS- CoV-2 infection

Introduction. During the development and spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic, a new inflammatory response syndrome arose in newborns, defined as the multisystem inflammatory syndrome (MIS) in neonates (MIS-N). Case report. A term infant girl with a fever diagnosed with SARS-CoV-2 infection was admitted to the hospital. In laboratory findings, the values of lactate dehydrogen-ase, ferritin, interleukin-6, and D-dimer were elevated. Upon admission, dual parenteral antibiotic therapy (ceftazidime, vancomycin), and one day later, low molec-ular weight heparin (LMWH) therapy, was commenced. After five days of hospitalization and febrility, with nega-tive results of microbiological analyses and further dete-rioration of laboratory findings, intravenous immuno-globulin (IVIg) was administered at a dose of 2 g/kg for one day and methylprednisolone at a dose of 1 mg/kg/day for four days, after which the reduction of corticosteroid therapy was continued with prednisone.