CASZ1: Current Implications in Cardiovascular Diseases and Cancers

被引：4
|
作者：
Jian, Heng [1 ]
Poetsch, Ansgar [1 ,2 ]
机构：
[1] Nanchang Univ, Queen Mary Sch, Nanchang 330006, Peoples R China
[2] Nanchang Univ, Sch Basic Med Sci, Nanchang 330006, Peoples R China
来源：
BIOMEDICINES | 2023年 / 11卷 / 07期
关键词：
CASZ1; cell differentiation; cancer; cardiovascular disorders; TRANSCRIPTION FACTOR CASZ1; GENOME-WIDE ASSOCIATION; GENE-EXPRESSION; BLOOD-PRESSURE; DNA METHYLATION; NEUROBLASTOMA; GROWTH; CASTOR; MORPHOGENESIS; DETERMINANTS;
D O I：
10.3390/biomedicines11072079
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Castor zinc finger 1 (CASZ1) is a C2H2 zinc finger family protein that has two splicing variants, CASZ1a and CASZ1b. It is involved in multiple physiological processes, such as tissue differentiation and aldosterone antagonism. Genetic and epigenetic alternations of CASZ1 have been characterized in multiple cardiovascular disorders, such as congenital heart diseases, chronic venous diseases, and hypertension. However, little is known about how CASZ1 mechanically participates in the pathogenesis of these diseases. Over the past decades, at first glance, paradoxical influences on cell behaviors and progressions of different cancer types have been discovered for CASZ1, which may be explained by a "double-agent" role for CASZ1. In this review, we discuss the physiological function of CASZ1, and focus on the association of CASZ1 aberrations with the pathogenesis of cardiovascular diseases and cancers.
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页数：18
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