Protective mechanisms of intra- and extracellular polysaccharides from Schizophyllum commune on H2O2-induced oxidative damage of human skin fibroblasts

被引：8
|
作者：
Cheng, Wenjing [1 ,2 ,3 ]
Yang, Yundong [1 ,2 ,3 ]
Zhang, Jiachan [1 ,2 ,3 ,5 ]
Di, Fei qian [1 ,2 ,3 ]
Li, Luyao [1 ,2 ,3 ]
Wang, Changtao [1 ,2 ,3 ]
Li, Meng [1 ,2 ,3 ]
Zhao, Dan [1 ,2 ,3 ]
Shi, Xiuqin [4 ]
Huo, Tong [4 ]
An, Quan [4 ]
机构：
[1] Beijing Technol & Business Univ, Coll Chem & Mat Engn, Beijing, Peoples R China
[2] Beijing Technol & Business Univ, Beijing Key Lab Plant Resource Res & Dev, Beijing, Peoples R China
[3] Beijing Technol & Business Univ, Inst Cosmet Regulatory Sci, Beijing, Peoples R China
[4] Yunnan Baiyao Grp Co Ltd, Kunming 2203407, Peoples R China
[5] Beijing Technol & Business Univ, Coll Chem & Mat Engn, 11 Fucheng Rd,Haidian Dist, Beijing 100048, Peoples R China
来源：
FOOD AND AGRICULTURAL IMMUNOLOGY | 2023年 / 34卷 / 01期
关键词：
Schizophyllum commune; polysaccharide; anti-oxidation; Keap1-Nrf2; ARE signalling pathway; CHEMICAL-CHARACTERIZATION; ANTIOXIDATIVE ACTIVITIES; COLLAGEN HYDROLYSATE; FREE-RADICALS; STRESS; EXPRESSION; LUCIDUM; ACID; NRF2; RATS;
D O I：
10.1080/09540105.2023.2203407
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Schizophyllum commune is a fungus with applications both in medicine and foods, which produces IPS and EPS. However, there is no comparative study on the activity comparison of IPS and EPS and its mechanism of antioxidant effect. In this study, the antioxidant activities of the two polysaccharides were measured in biochemical, cellular and molecular levels, and H2O2 induced oxidative damage model of HSFs was established to explore the protective effects of EPS and IPS. We found IPS and EPS both achieved a good antioxidant effect. They can also improve the cellular levels of SOD and reduce MDA. Insights regarding the molecular mechanism were studied, we found that both EPS and IPS could increase the expression of Nrf2 in Keap1-Nrf2/ARE signaling pathway. At the same time, they could inhibit the expression of the negative feedback gene Keap1 and promote the expression of downstream gene GCLC, Gstt-1, Nqo1 and Ho-1.
引用
收藏
页数：18
相关论文
共 50 条
  • [31] Protective Effects of Curcumin and Its Metabolites on H2O2-Induced Oxidative Damage in PC12 Cells
    Li H.
    Huang Y.
    Wang Y.
    Li D.
    Li F.
    Shipin Kexue/Food Science, 2020, 41 (15): : 208 - 215
  • [32] Protective Mechanism of Leucine and Isoleucine against H2O2-Induced Oxidative Damage in Bovine Mammary Epithelial Cells
    Wu, Sainan
    Liu, Xize
    Cheng, Long
    Wang, Duojia
    Qin, Guixin
    Zhang, Xuefeng
    Zhen, Yuguo
    Wang, Tao
    Sun, Zhe
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2022, 2022
  • [33] The Protective Effects of KBD on Antioxidant Enzyme in H2O2-induced Oxidative Damage of PC12 Cells
    Xu, Y. H.
    Ye, S. F.
    Wang, T. T.
    Su, Y. Y.
    Wang, H. J.
    Wu, L. N.
    Cai, J.
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2014, 62 : S358 - S358
  • [34] Protective Effects of Lycopene against H2O2-Induced Oxidative Injury and Apoptosis in Human Endothelial Cells
    XiangYu Tang
    XiangDong Yang
    YaFei Peng
    JunHua Lin
    Cardiovascular Drugs and Therapy, 2009, 23 : 439 - 448
  • [35] Protective Effects of Lycopene against H2O2-Induced Oxidative Injury and Apoptosis in Human Endothelial Cells
    Tang, XiangYu
    Yang, XiangDong
    Peng, YaFei
    Lin, JunHua
    CARDIOVASCULAR DRUGS AND THERAPY, 2009, 23 (06) : 439 - 448
  • [36] Protective Effects and Mechanisms of Esculetin against H2O2-Induced Oxidative Stress, Apoptosis, and Pyroptosis in Human Hepatoma HepG2 Cells
    Luo, Ying
    Chang, Tenglong
    Huang, Shiting
    Xiang, Jing
    Tang, Shuangyang
    Shen, Haiyan
    MOLECULES, 2024, 29 (07):
  • [37] The protective effects of Achillea L. species native in Turkey against H2O2-induced oxidative damage in human erythrocytes and leucocytes
    Konyalioglu, S
    Karamenderes, C
    JOURNAL OF ETHNOPHARMACOLOGY, 2005, 102 (02) : 221 - 227
  • [38] In Vitro Evaluation of Anti-Inflammatory and Protective Potential of an Extract from Cornus mas L. Fruit against H2O2-Induced Oxidative Stress in Human Skin Keratinocytes and Fibroblasts
    Wojciak, Magdalena
    Zagorska-Dziok, Martyna
    Niziol-Lukaszewska, Zofia
    Ziemlewska, Aleksandra
    Furman-Toczek, Dominika
    Szczepanek, Dariusz
    Sowa, Ireneusz
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (22)
  • [39] Protective effect of Sargassum fusiforme polysaccharides on H2O2-induced injury in LO2 cells
    Li, Jiarui
    Wang, Zhuo
    Chen, Jianping
    Luo, Baozhen
    Chen, Xuehua
    Li, Rui
    Gao, Jialong
    Liu, Xiaofei
    Song, Bingbing
    Zhong, Saiyi
    FRONTIERS IN MARINE SCIENCE, 2023, 9
  • [40] Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cells
    Gao, Shasha
    Qin, Tingyu
    Liu, Zhenzhen
    Caceres, Maria Andrea
    Ronchi, Carlos F.
    Chen, C-Y. Oliver
    Yeum, Kyung-jin
    Taylor, Allen
    Blumberg, Jeffery B.
    Liu, Yizhi
    Shang, Fu
    MOLECULAR VISION, 2011, 17 (342-43): : 3180 - 3190
12345