Metabolomic Analysis Reveals Association between Decreased Ovarian Reserve and In Vitro Fertilization Outcomes

被引:0
|
作者
An, Na [1 ,2 ]
Zhang, Min [3 ,4 ,5 ]
Zhu, Quan-Fei [2 ]
Chen, Yao-Yu [1 ]
Deng, Yan-Ling [3 ,4 ,5 ]
Liu, Xiao-Ying [3 ,4 ,5 ]
Zeng, Qiang [3 ,4 ,5 ]
Feng, Yu-Qi [2 ]
机构
[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China
[2] Wuhan Text Univ, Sch Bioengn & Hlth, Wuhan 430200, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan 430030, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan 430030, Peoples R China
[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating,Minist Envi, Wuhan 430030, Peoples R China
关键词
in vitro fertilization; diminished ovarian reserve; metabolomics; human serum; ASSISTED REPRODUCTIVE TECHNOLOGY; FOLLICULAR-FLUID; OOCYTE; APOPTOSIS; MARKERS; STRESS;
D O I
10.3390/metabo14030143
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In vitro fertilization (IVF) is a highly effective treatment for infertility; however, it poses challenges for women with decreased ovarian reserve (DOR). Despite the importance of understanding the impact of DOR on IVF outcomes, limited research has explored this relationship, particularly using omics approaches. Hence, we conducted a study to investigate the association between DOR and IVF outcomes, employing a metabolomic approach. We analyzed serum samples from 207 women undergoing IVF treatment, including 89 with DOR and 118 with normal ovarian reserve (NOR). Our findings revealed that DOR was significantly associated with unfavorable IVF outcomes, characterized by a reduced oocyte count, lower embryo quality, and decreased rates of pregnancy and live births. Furthermore, we identified 82 metabolites that displayed significant alterations in DOR patients, impacting diverse metabolic pathways. Notably, a distinct panel of metabolites, including palmitic acid, stearic acid, LysoPC(9:0(CHO)/0:0), PC(18:0/9:0(CHO)), and PC(16:0/9:0(CHO)), exhibited discriminatory power between the DOR and NOR groups, showcasing a strong correlation with IVF outcomes. These findings emphasize the crucial role of metabolomic disruptions in influencing IVF outcomes among women with DOR.
引用
下载
收藏
页数:18
相关论文
共 50 条
  • [41] Ovarian Reserve Test with Human Menopausal Gonadotropin as a Predictor of In Vitro Fertilization Outcome
    Francisco Fábregues
    Juan Balasch
    Montserrat Creus
    Francisco Carmona
    Bienvenido Puerto
    Llorenç Quinto
    Roser Casamitjana
    Juan A. Vanrell
    Journal of Assisted Reproduction and Genetics, 2000, 17 : 13 - 19
  • [42] Ovarian reserve test with human menopausal gonadotropin as a predictor of in vitro fertilization outcome
    Fábregues, F
    Balasch, J
    Creus, M
    Carmona, F
    Puerto, B
    Quintó, L
    Casamitjana, R
    Vanrell, JA
    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2000, 17 (01) : 13 - 19
  • [43] Change in oocyte yield in repeated in vitro fertilization cycles: effect of ovarian reserve
    Eppsteiner, Erin E.
    Sparks, Amy E. T.
    Liu, Dawei
    Van Voorhis, Bradley J.
    FERTILITY AND STERILITY, 2014, 101 (02) : 399 - 402
  • [44] Effects of transcutaneous electrical acupoint stimulation on ovarian reserve of patients with diminished ovarian reserve in in vitro fertilization and embryo transfer cycles
    Zheng, Ying
    Feng, Xiaojun
    Mi, Hui
    Yao, Yi
    Zhao, Yu
    Li, Jing
    Jiao, Jiao
    Gong, Ailing
    Sun, Wei
    Deng, Xiaohui
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2015, 41 (12) : 1905 - 1911
  • [45] Live birth of twins after performing early hCG administration as a modification of natural cycle in vitro fertilization, in a women with decreased ovarian reserve
    Jordana H. Hyman
    Tamar Sokal-Arnon
    Weon-Young Son
    Seang Lin Tan
    Michael H. Dahan
    Archives of Gynecology and Obstetrics, 2015, 291 : 219 - 222
  • [46] Improved pregnancy outcome for women with decreased ovarian oocyte reserve and advanced reproductive age by performing in vitro fertilization-embryo transfer
    Check, J. H.
    Pinto, J.
    Liss, J. R.
    Choe, J. K.
    CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, 2008, 35 (03): : 167 - 169
  • [47] Live birth of twins after performing early hCG administration as a modification of natural cycle in vitro fertilization, in a women with decreased ovarian reserve
    Hyman, Jordana H.
    Sokal-Arnon, Tamar
    Son, Weon-Young
    Tan, Seang Lin
    Dahan, Michael H.
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2015, 291 (01) : 219 - 222
  • [48] Association between neighborhood poverty and ovarian reserve: the ovarian aging study
    Pan, Anwesha
    Crowder, Kyle D.
    Cedars, Marcelle I.
    Bleil, Maria E.
    MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2024, 31 (05): : 372 - 380
  • [49] Duration of ovarian stimulation is predictive of in-vitro fertilization outcomes
    Sarkar, Papri
    Ying, Luke
    Plosker, Shayne
    Mayer, James
    Ying, Ying
    Imudia, Anthony N.
    MINERVA GINECOLOGICA, 2019, 71 (06): : 419 - 426
  • [50] Association of leptin with poor ovarian stimulation during in vitro fertilization
    Robins, JC
    Srivastava, R
    Mershon, JL
    Thomas, MA
    JOURNAL OF REPRODUCTIVE MEDICINE, 2005, 50 (05) : 356 - 360