Metabolomic Analysis Reveals Association between Decreased Ovarian Reserve and In Vitro Fertilization Outcomes

被引:0
|
作者
An, Na [1 ,2 ]
Zhang, Min [3 ,4 ,5 ]
Zhu, Quan-Fei [2 ]
Chen, Yao-Yu [1 ]
Deng, Yan-Ling [3 ,4 ,5 ]
Liu, Xiao-Ying [3 ,4 ,5 ]
Zeng, Qiang [3 ,4 ,5 ]
Feng, Yu-Qi [2 ]
机构
[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China
[2] Wuhan Text Univ, Sch Bioengn & Hlth, Wuhan 430200, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan 430030, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan 430030, Peoples R China
[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating,Minist Envi, Wuhan 430030, Peoples R China
关键词
in vitro fertilization; diminished ovarian reserve; metabolomics; human serum; ASSISTED REPRODUCTIVE TECHNOLOGY; FOLLICULAR-FLUID; OOCYTE; APOPTOSIS; MARKERS; STRESS;
D O I
10.3390/metabo14030143
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In vitro fertilization (IVF) is a highly effective treatment for infertility; however, it poses challenges for women with decreased ovarian reserve (DOR). Despite the importance of understanding the impact of DOR on IVF outcomes, limited research has explored this relationship, particularly using omics approaches. Hence, we conducted a study to investigate the association between DOR and IVF outcomes, employing a metabolomic approach. We analyzed serum samples from 207 women undergoing IVF treatment, including 89 with DOR and 118 with normal ovarian reserve (NOR). Our findings revealed that DOR was significantly associated with unfavorable IVF outcomes, characterized by a reduced oocyte count, lower embryo quality, and decreased rates of pregnancy and live births. Furthermore, we identified 82 metabolites that displayed significant alterations in DOR patients, impacting diverse metabolic pathways. Notably, a distinct panel of metabolites, including palmitic acid, stearic acid, LysoPC(9:0(CHO)/0:0), PC(18:0/9:0(CHO)), and PC(16:0/9:0(CHO)), exhibited discriminatory power between the DOR and NOR groups, showcasing a strong correlation with IVF outcomes. These findings emphasize the crucial role of metabolomic disruptions in influencing IVF outcomes among women with DOR.
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页数:18
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