KOtBu-catalysed α-homoallylic alkylation of acyclic amides with 1-aryl-1,3-dienes

被引：1
|
作者：
Xiang, Yunfei [1 ]
Du, Ruisheng [1 ]
Wang, Shang [1 ]
Wu, Xiang [1 ]
Tang, Jie [1 ]
Yang, Fan [1 ]
Xing, Dong [1 ]
机构：
[1] East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China
来源：
MOLECULAR DIVERSITY | 2023年 / 27卷 / 03期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Amide; Diene; Transition metal-free; Homoallylic alkylation; KOtBu; POTASSIUM TERT-BUTOXIDE; 1,4-ADDITION REACTIONS; KETONES; ARYLACETYLENES; VINYLATION; NITRILES; OLEFINS; DERIVATIVES; SEARCH;
D O I：
10.1007/s11030-022-10503-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Herein, we report a KOtBu-catalysed alpha-homoallylic alkylation of acyclic amides with 1-aryl-1,3-dienes. With this transition metal-free and atom-economic protocol, a series of alpha-homoallylic alkylated acyclic amides were synthesized in good to excellent yields. This transformation is proposed to proceed through a cation-pi interaction-based C-C bond formation from the in situ-generated potassium enolate with the diene unit. [GRAPHICS] .
引用
收藏
页码：1481 / 1487
页数：7
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