Radiotherapy for Non-Hodgkin's lymphoma with cardiac infiltration: A case report

被引：1

作者：

Wang, Weifeng ^{[1
]}

Zhang, Zhuo ^{[1
]}

Deng, Xiaocong ^{[1
]}

Gu, Anqi ^{[1
]}

Chen, Xianzhao ^{[1
]}

Cai, Yizheng ^{[1
]}

Zhao, Yuting ^{[1
]}

机构：

[1] Hainan Canc Hosp, Dept Radiat Oncol, Haikou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 13卷

关键词：

Non-Hodgkin's lymphoma; cardiac infiltration; radiotherapy; zanubrutinib; case report; INVOLVEMENT;

D O I：

10.3389/fonc.2023.1234831

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundNon-Hodgkin's lymphoma (NHL) with cardiac infiltration has a poor prognosis. The median OS of patients failing to respond to chemotherapy has been reported to be 1 month vs. 18 months in patients responding to chemotherapy.Case presentationHerein, we reported a case of a 57-year-old male confirmed with diffuse large B-cell lymphoma who received radiation therapy of 150-cGy daily, administered in 30 fractions to the volume of cardiac infiltration, resulting in complete relief. Chemotherapy had no curative effect. The patient was subsequently enrolled in a clinical trial and received oral administration of zanubrutinib 80mg twice daily, after which he achieved complete remission. The progression-free survival was from diagnosis (January 7, 2020) to the follow-up (September 20, 2022), amounting to 32 months.ConclusionProper irradiation dose and timing of treatment can relieve NHL symptoms.

引用

页数：5

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