Effectiveness of the pre-Omicron COVID-19 vaccines against Omicron in reducing infection, hospitalization, severity, and mortality compared to Delta and other variants: A systematic review

被引：19

作者：

Paul, Pradipta ^{[1
]}

El-Naas, Ahmed ^{[1
]}

Hamad, Omar ^{[1
]}

Salameh, Mohammad A. ^{[1
,2
]}

Mhaimeed, Nada ^{[1
]}

Laswi, Ibrahim ^{[1
]}

Abdelati, Ali A. ^{[1
]}

AlAnni, Jamal ^{[1
,3
]}

Khanjar, Bushra ^{[1
,4
]}

Al-Ali, Dana ^{[1
,5
]}

Pillai, Krishnadev V. ^{[1
]}

Elshafeey, Abdallah ^{[1
,6
]}

Alroobi, Hasan ^{[1
]}

Burney, Zain ^{[1
,7
]}

Mhaimeed, Omar ^{[1
,6
]}

Bhatti, Mohammad ^{[1
]}

Sinha, Pratyaksha ^{[1
]}

Almasri, Muna ^{[1
]}

Aly, Ahmed ^{[1
]}

Bshesh, Khalifa ^{[1
]}

Chamseddine, Reem ^{[1
]}

Khalil, Omar ^{[1
]}

D'Souza, Ashton ^{[1
]}

Shree, Thanu ^{[1
,8
]}

Mhaimeed, Narjis ^{[1
]}

Yagan, Lina ^{[1
,9
]}

Zakaria, Dalia ^{[1
,10
]}

机构：

[1] Cornell Univ, Weill Cornell Med Qatar, Qatar Fdn, Doha, Qatar

[2] Mayo Clin, Dept Obstet & Gynecol, Rochester, MN USA

[3] Cincinnati Childrens Hosp Med Ctr CCHMC, Dept Pediat, Cincinnati, OH USA

[4] Hamad Med Corp, Dept Dermatol, Doha, Qatar

[5] Hamad Med Corp, Dept Pediat, Doha, Qatar

[6] Johns Hopkins Univ Hosp, Dept Med, Baltimore, MD USA

[7] Cleveland Clin, Med Inst, Cleveland, OH USA

[8] Hamad Med Corp, Doha, Qatar

[9] Univ Penn Hosp, Dept Med, Philadelphia, PA USA

[10] Cornell Univ, Qatar Fdn, Weill Cornell Med Qatar, Al Luqta St Ar-Rayyan,POB 24144, Doha, Qatar

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2023年 / 19卷 / 01期

关键词：

Omicron; Delta; Alpha; SARS-CoV-2; COVID-19; effectiveness; vaccine; COVID-19-ASSOCIATED EMERGENCY-DEPARTMENT; URGENT CARE ENCOUNTERS; VISION NETWORK; 10; STATES; VACCINATION; ADOLESCENTS; CHILDREN;

D O I：

10.1080/21645515.2023.2167410

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Despite widespread mass rollout programs, the rapid spread of the SARS-CoV-2 Omicron variant called into question the effectiveness of the existing vaccines against infection, hospitalization, severity, and mortality compared to previous variants. This systematic review summarizes and compares the effectiveness of the COVID-19 vaccines, with respect to the above outcomes in adults, children, and adolescents. A comprehensive literature search was undertaken on several databases. Only 51 studies met our inclusion criteria, revealing that the protection from primary vaccination against Omicron infection is inferior to protection against Delta and Alpha infections and wanes faster over time. However, mRNA vaccine boosters were reported to reestablish effectiveness, although to a lower extent against Omicron. Nonetheless, primary vaccination was shown to preserve strong protection against Omicron-associated hospitalization, severity, and death, even months after last dose. However, boosters provide more robust and longer-lasting protection against hospitalizations due to Omicron as compared to only primary series.

引用

页数：23

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