Practical synthesis of unsymmetrical disulfides promoted by bromodimethylsulfonium bromide

被引：5

作者：

Dong, Bo ^{[1
]}

Chen, Yifeng ^{[1
]}

Xie, Shubing ^{[3
]}

Zhang, Jieying ^{[1
]}

Shen, Jian ^{[1
,2
]}

Xie, Lan-Gui ^{[1
]}

机构：

[1] Nanjing Normal Univ, Natl & Local Joint Engn Res Ctr Biomed Funct Mat, Sch Chem & Mat Sci, Nanjing 210023, Peoples R China

[2] Nanjing Univ, Jiangsu Engn Res Ctr Interfacial Chem, Nanjing 210023, Peoples R China

[3] Anhui Changjiang Inst Metrol, Hefei 230088, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 05期

基金：

中国国家自然科学基金;

关键词：

EFFICIENT SYNTHESIS; DISULFANES; PRECURSORS; ALKENES; THIOLS; BONDS;

D O I：

10.1039/d2ob02124b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidative cross-coupling of two thiols is the most direct tool for the synthesis of unsymmetrical disulfides and highly desirable across academia and industry. However, the inevitable formation of significant amounts of the corresponding symmetrical by-products is a major issue. We herein present a method toward the synthesis of unsymmetrical disulfides in which the homo-coupling of the thiols is effectively inhibited by adding the two thiols sequentially, taking advantage of rapid oxidation of the thiol by bromodimethylsulfonium bromide.

引用

页码：930 / 934

页数：5

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