Bempedoic Acid: A Contemporary Review of Its Pharmacology, Efficacy, and Safety Profile, Including Recent Data from the CLEAR Outcomes Clinical Trial

被引：1
|
作者：
Park, Jong Kun [1 ]
Balarbar, Noah [2 ]
Agarwala, Anandita [2 ]
机构：
[1] Univ Texas Hlth Sci Ctr Houston, Houston, TX USA
[2] Baylor Scott & White Hlth Heart Hosp Baylor Plano, Ctr Cardiovasc Dis Prevent, Plano, TX 75093 USA
来源：
CURRENT CARDIOLOGY REPORTS | 2023年 / 25卷 / 9期
关键词：
Bempedoic acid; Statin intolerance; LDL cholesterol; CLEAR Outcomes; Women's inclusion; ATP-CITRATE-LYASE; DENSITY-LIPOPROTEIN-CHOLESTEROL; ACTIVATED PROTEIN-KINASE; CORONARY-HEART-DISEASE; PRIMARY-PREVENTION; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; LDL CHOLESTEROL; RISK; PRAVASTATIN;
D O I：
10.1007/s11886-023-01911-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose of ReviewTo provide an updated review of bempedoic acid's clinical application in lowering LDL-C in the setting of statin intolerance and the recent findings in the CLEAR Outcomes trial as well as summarize and synthesize the current state of knowledge regarding bempedoic acid while providing an in-depth analysis of the drug's pharmacological properties, mechanism of action, clinical trials, safety, and efficacy.Recent FindingsThe CLEAR Outcomes trial has provided evidence to support bempedoic acid as a viable alternative to statins for the primary and secondary prevention of cardiovascular disease.Bempedoic acid is a promising treatment option for patients with hypercholesterolemia who are unable to tolerate statin therapy or require additional LDL-C reduction in the treatment of cardiovascular disease, with the newest lipid-lowering cardiovascular outcomes trials expanding on their generalizability particularly in the inclusion of women.
引用
收藏
页码：969 / 978
页数：10
相关论文
共 50 条
  • [41] Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives
    Mullangi, Ramesh
    Ahlawat, Preeti
    Srinivas, Nuggehally R.
    BIOMEDICAL CHROMATOGRAPHY, 2010, 24 (01) : 104 - 123
  • [42] Safety Profile of Ceftazidime–Avibactam: Pooled Data from the Adult Phase II and Phase III Clinical Trial Programme
    Karen Cheng
    Paul Newell
    Joseph W. Chow
    Helen Broadhurst
    David Wilson
    Katrina Yates
    Angela Wardman
    Drug Safety, 2020, 43 : 751 - 766
  • [43] TRAZODONE HYDROCHLORIDE - A WIDE SPECTRUM ANTI-DEPRESSANT WITH A UNIQUE PHARMACOLOGICAL PROFILE - A REVIEW OF ITS NEUROCHEMICAL EFFECTS, PHARMACOLOGY, CLINICAL EFFICACY, AND TOXICOLOGY - COMMENTARY
    SMALL, JG
    PHARMACOTHERAPY, 1982, 2 (05): : 265 - 265
  • [44] SAFETY AND EFFICACY OF BEVACIZUMAB PLUS TTFIELDS IN PATIENTS WITH RECURRENT GLIOBLASTOMA (GBM): DATA FROM A PHASE II CLINICAL TRIAL
    Fallah, Jaleh
    Chaudhary, Rekha
    Rogers, Lisa
    Wei, Wei
    Brewer, Cathy
    Peereboom, David
    Ahluwalia, Manmeet
    NEURO-ONCOLOGY, 2019, 21 : 18 - 18
  • [45] Efficacy and safety of dulaglutide in the treatment of type 2 diabetes: a comprehensive review of the dulaglutide clinical data focusing on the AWARD phase 3 clinical trial program
    Jendle, Johan
    Grunberger, George
    Blevins, Thomas
    Giorgino, Francesco
    Hietpas, Ryan T.
    Botros, Fady T.
    DIABETES-METABOLISM RESEARCH AND REVIEWS, 2016, 32 (08) : 776 - 790
  • [46] Safety Profile of Ceftazidime-Avibactam: Pooled Data from the Adult Phase II and Phase III Clinical Trial Programme
    Cheng, Karen
    Newell, Paul
    Chow, Joseph W.
    Broadhurst, Helen
    Wilson, David
    Yates, Katrina
    Wardman, Angela
    DRUG SAFETY, 2020, 43 (08) : 751 - 766
  • [47] Gadobutrol for contrast-enhanced magnetic resonance imaging in elderly patients: review of the safety profile from clinical trial, post-marketing surveillance, and pharmacovigilance data
    Endrikat, J.
    Schwenke, C.
    Prince, M. R.
    CLINICAL RADIOLOGY, 2015, 70 (07) : 743 - 751
  • [48] Critical review of oral drug treatments for diabetic neuropathic pain - clinical outcomes based on efficacy and safety data from placebo-controlled and direct comparative studies
    Adriaensen, H
    Plaghki, L
    Mathieu, C
    Joffroy, A
    Vissers, K
    DIABETES-METABOLISM RESEARCH AND REVIEWS, 2005, 21 (03) : 231 - 240
  • [49] TRANSOBTURATOR MALE SLING AT THE TIME OF ROBOTIC ASSISTED, LAPAROSCOPIC RADICAL PROSTATECTOMY YIELDS IMPROVED CONTINENCE OUTCOMES: DATA FROM A RANDOMIZED CLINICAL TRIAL DEMONSTRATING SAFETY AND EFFICACY.
    Christine, B.
    Bivins, V. M.
    Tully, A. S.
    Bugg, C.
    Bella, A.
    McGwin, G., Jr.
    NEUROUROLOGY AND URODYNAMICS, 2011, 30 (06) : 999 - 1000
  • [50] NIVOLUMAB RE-TREATMENT IN PATIENTS WITH RELAPSED/REFRACTORY HODGKIN LYMPHOMA: SAFETY AND EFFICACY OUTCOMES FROM A PHASE 1 CLINICAL TRIAL
    Ansell, S.
    Armand, P.
    Timmerman, J.
    Shipp, M.
    Mckiver, M. Popa
    Zhu, L.
    Lesokhin, A. M.
    HAEMATOLOGICA, 2016, 101 : 49 - 49
12345