Therapeutic potential of MSCs and MSC-derived extracellular vesicles in immune thrombocytopenia

被引：5
|
作者：
Wu, Feifeng [1 ]
She, Zhou [1 ]
Li, Cuifang [1 ]
Mao, Jueyi [1 ]
Luo, Senlin [1 ]
Chen, Xiaoyu [1 ]
Tian, Jidong [1 ]
Wen, Chuan [1 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Pediat, Changsha 410011, Peoples R China
来源：
STEM CELL RESEARCH & THERAPY | 2023年 / 14卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Immune thrombocytopenia; Mesenchymal stem cells; Cellular therapy; Extracellular vesicles; MESENCHYMAL STEM-CELLS; COMPLEMENT ACTIVATION; PURPURA; EXPRESSION; APOPTOSIS; SOCIETY;
D O I：
10.1186/s13287-023-03323-6
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Immune thrombocytopenia (ITP) is an acquired autoimmune disease involving a variety of immune cells and factors. Despite being a benign disease, it is still considered incurable due to its complex pathogenesis. Mesenchymal stem cells (MSCs), with low immunogenicity, pluripotent differentiation, and immunomodulatory ability, are widely used in a variety of autoimmune diseases. In recent years, impaired bone marrow mesenchymal stem cells (BMMSCs) were found to play an important role in the pathogenesis of ITP; and the therapeutic role of MSCs in ITP has also been supported by increasing evidence with encouraging efficacy. MSCs hold promise as a new approach to treat or even cure refractory ITP. Extracellular vesicles (EVs), as novel carriers in the "paracrine" mechanism of MSCs, are the focus of MSCs. Encouragingly, several studies suggested that EVs may perform similar functions as MSCs to treat ITP. This review summarized the role of MSCs in the pathophysiology and treatment of ITP.
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页数：9
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