Cardiovascular health-related quality of life in cancer: a prospective study comparing the ESC HeartQoL and EORTC QLQ-C30 questionnaire

被引：2

作者：

Anker, Markus S. ^{[1
,2
,3
,4
,5
,6
]}

Potthoff, Sophia K. ^{[2
,3
,4
,5
,6
]}

Lena, Alessia ^{[1
,2
,3
,4
,5
]}

Porthun, Jan ^{[8
]}

Hadzibegovic, Sara ^{[1
,2
,3
,4
,5
,6
]}

Evertz, Ruben ^{[9
,10
]}

Denecke, Corinna ^{[2
,3
,4
,7
]}

Froehlich, Ann-Kathrin ^{[2
,3
,4
,5
,6
,7
]}

Sonntag, Frederike ^{[2
,3
,4
,5
,6
,7
]}

Regitz-Zagrosek, Vera ^{[11
,12
]}

Rosen, Stuart D. ^{[13
,14
,15
]}

Lyon, Alexander R. ^{[13
,14
,15
]}

Luescher, Thomas F. ^{[13
,14
,15
,16
,17
]}

Spertus, John A. ^{[18
,19
]}

Anker, Stefan D. ^{[2
,3
,5
,6
,7
]}

Karakas, Mahir ^{[20
,21
]}

Bullinger, Lars ^{[22
,23
,24
,25
,26
]}

Keller, Ulrich ^{[22
,23
,27
,28
]}

Landmesser, Ulf ^{[1
,3
,4
,5
,29
]}

Butler, Javed ^{[30
,31
]}

von Haehling, Stephan ^{[9
,10
]}

机构：

[1] Deutsch Herzzentrum Charite, Dept Cardiol Angiol & Intens Care Med CBF, Berlin, Germany

[2] Charite Univ Med Berlin, Berlin, Germany

[3] Free Univ Berlin, Berlin, Germany

[4] Humboldt Univ, Berlin, Germany

[5] German Ctr Cardiovasc Res DZHK, Partner site Berlin, Berlin, Germany

[6] Berlin Inst Hlth Ctr Regenerat Therapies BCRT, Berlin, Germany

[7] Deutsch Herzzentrum Charite, Dept Cardiol Angiol & Intens Care Med CVK, Berlin, Germany

[8] Norwegian Univ Sci & Technol, Gjovik, Norway

[9] Univ Gottingen, Med Ctr, Dept Cardiol & Pneumol, Gottingen, Germany

[10] German Ctr Cardiovasc Res DZHK, Partner site Gottingen, Gottingen, Germany

[11] Charite Univ Med Berlin, Inst Gender Med, Berlin, Germany

[12] Univ Zurich, Fac Med, Zurich, Switzerland

[13] Royal Brompton Hosp, Cardiooncol Serv, London, England

[14] Natl Heart & Lung Inst, London, England

[15] Royal Brompton & Harefield Hosp, Heart Div, London, England

[16] Imperial Coll London, Natl Heart & Lung Inst, London, England

[17] Univ Zurich, Ctr Mol Cardiol, Zurich, Switzerland

[18] Univ Missouri, Kansas Citys Healthcare Inst Innovat Qual, Kansas City, MI USA

[19] St Lukes Mid Amer Heart Inst, Kansas City, MI USA

[20] German Ctr Cardiovasc Res DZHK, Partner site HH Kiel HL, Hamburg, Germany

[21] Univ Med Ctr Hamburg Eppendorf, Dept Intens Care Med, Hamburg, Germany

[22] German Canc Res Ctr, Heidelberg, Germany

[23] German Canc Consortium, Heidelberg, Germany

[24] Charite Univ Med Berlin, Dept Hematol Oncol & Tumor Immunol CVK, Berlin, Germany

[25] Free Univ Berlin, Berlin, Germany

[26] Humboldt Univ, Berlin, Germany

[27] Charite Univ Med Berlin, Dept Hematol Oncol & Canc Immunol, Berlin, Germany

[28] Max Delbruck Ctr, Berlin, Germany

[29] Charite Univ Med Berlin, Berlin Inst Hlth BIH, Berlin, Germany

[30] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS USA

[31] Baylor Scott & White Res Inst, Dallas, TX USA

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2023年 / 25卷 / 09期

关键词：

Quality of life; Cancer; EORTC QLQ-C30; HeartQoL; FAILURE ASSOCIATION; POSITION PAPER; BREAST-CANCER; SURVIVAL; DISEASE; CLASSIFICATION; STATISTICS; VALIDATION; GUIDELINES; COMMITTEE;

D O I：

10.1002/ejhf.2951

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims Health-related quality of life (HRQoL) is highly relevant in cancer and often assessed with the EORTC QLQ-C30. Cardiovascular HRQoL in cancer can be measured with the ESC HeartQoL questionnaire. We compared these instruments and examined their prognostic value. Methods and results Summary scores for EORTC QLQ-C30 (0-100 points) and ESC HeartQoL (0-3 points) questionnaires were prospectively assessed in 290 patients with mostly advanced cancer (stage 3/4: 81%, 1-year mortality: 36%) and 50 healthy controls (similar age and sex). Additionally, physical function and activity assessments were performed. Both questionnaires demonstrated reduced HRQoL in patients with cancer versus controls (EORTC QLQ-C30: 67 +/- 20 vs. 91 +/- 11, p < 0.001; ESC HeartQoL: 1.8 +/- 0.8 vs. 2.7 +/- 0.4, p < 0.001). The instruments were strongly correlated with each other (summary scores [r = 0.76], physical [r = 0.81], and emotional subscales [r = 0.75, all p < 0.001]) and independently associated with all-cause mortality (best cut-offs: EORTC QLQ-C30 <82.69:hazard ratio [HR] 2.33, p= 0.004; ESC HeartQoL <1.50: HR 1.85, p= 0.004 - adjusted for sex, age, left ventricular ejection fraction, N-terminal pro-B-type natriuretic peptide [NT-proBNP], high-sensitivity troponin T, cancer stage/type), with no differences in the strength of the association by sex (p-interaction > 0.9). Combining both questionnaires identified three risk groups with highest mortality in patients below both cut-offs (vs. patients above both cut-offs: HR 3.60, p < 0.001). Patients with results below both cut-offs, showed higher NT-proBNP and reduced physical function and activity. Conclusions The EORTC QLQ-C30 and ESC HeartQoL - assessing cancer and cardiovascular HRQoL - are both associated with increased mortality in cancer patients, with even greater stratification by combing both. Reduced HRQoL scores were associated with elevated cardiovascular biomarkers and decreased functional status.

引用

页码：1635 / 1647

页数：13

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