Pseudo-Marginal Inference for CTMCs on Infinite Spaces via Monotonic Likelihood Approximations

Bayesian inference for Continuous-Time Markov chains (CTMCs) on countably infinite spaces is notoriously difficult because evaluating the likelihood exactly is intractable. One way to address this challenge is to first build a nonnegative and unbiased estimate of the likelihood-involving the matrix exponential of finite truncations of the true rate matrix-and then to use the estimates in a pseudo-marginal inference method. In this work, we show that we can dramatically increase the efficiency of this approach by avoiding the computation of exact matrix exponentials. In particular, we develop a general methodology for constructing an unbiased, nonnegative estimate of the likelihood using doubly-monotone matrix exponential approximations. We further develop a novel approximation in this family-the skeletoid-as well as theory regarding its approximation error and how that relates to the variance of the estimates used in pseudo-marginal inference. Experimental results show that our approach yields more efficient posterior inference for a wide variety of CTMCs. Supplementary materials for this article are available online.