Rhodium Catalyzed [4+1]-Annulation of o-Acylanilines with 3-Diazoindoline-2-imines

被引：1

作者：

Rupa, Kavuri ^{[1
]}

Anbarasan, Pazhamalai ^{[1
]}

机构：

[1] Indian Inst Technol Madras, Dept Chem, Chennai 600036, India

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 34期

关键词：

DIASTEREOSELECTIVE SYNTHESIS; NATURAL-PRODUCTS; 3-DIAZOINDOLIN-2-IMINES; INDOLINES; UTILITY; YLIDES;

D O I：

10.1021/acs.orglett.3c02288

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient rhodium catalyzed [4 + 1]-annulation of o-acylanilines with 3-diazoindoline-2-imines has been successfullyaccomplished for the synthesis of spiroindolines in good to excellentyield. The reaction occurs through formation of N-ylide followed by cyclization and showed good tolerance to variousfunctional groups. Gram-scale synthesis, diastereoselective constructionof tetrasubstituted indoline, synthesis of spirooxindole, and isolationof potential intermediates have also been demonstrated.

引用

页码：6357 / 6362

页数：6

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