Rhodium Catalyzed [4+1]-Annulation of o-Acylanilines with 3-Diazoindoline-2-imines

被引：1
|
作者：
Rupa, Kavuri [1 ]
Anbarasan, Pazhamalai [1 ]
机构：
[1] Indian Inst Technol Madras, Dept Chem, Chennai 600036, India
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 34期
关键词：
DIASTEREOSELECTIVE SYNTHESIS; NATURAL-PRODUCTS; 3-DIAZOINDOLIN-2-IMINES; INDOLINES; UTILITY; YLIDES;
D O I：
10.1021/acs.orglett.3c02288
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient rhodium catalyzed [4 + 1]-annulation of o-acylanilines with 3-diazoindoline-2-imines has been successfullyaccomplished for the synthesis of spiroindolines in good to excellentyield. The reaction occurs through formation of N-ylide followed by cyclization and showed good tolerance to variousfunctional groups. Gram-scale synthesis, diastereoselective constructionof tetrasubstituted indoline, synthesis of spirooxindole, and isolationof potential intermediates have also been demonstrated.
引用
收藏
页码：6357 / 6362
页数：6
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