ER stress and the unfolded protein response in gastrointestinal stem cells and carcinogenesis

被引：0

作者：

Boer, Ruben J. de ^{[1
,2
]}

Jeude, Jooske F. van Lidth de ^{[1
]}

Heijmans, Jarom ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Amsterdam, Amsterdam UMC, Tytgat Inst Liver & Intestinal Res, Amsterdam Gastroenterol Endocrinol Metab, Meibergdreef 69-71, Amsterdam, Netherlands

[2] Canc Ctr Amsterdam, Canc Biol & Immunol, Amsterdam, Netherlands

[3] Univ Amsterdam, Dept Gen Internal Med, Amsterdam UMC, Meibergdreef 9, Amsterdam, Netherlands

[4] Univ Amsterdam, Dept Hematol, Meibergdreef 9, Amsterdam, Netherlands

[5] Acad Med Ctr, Dept Internal Med, Amsterdam, Netherlands

来源：

CANCER LETTERS | 2024年 / 587卷

关键词：

ENDOPLASMIC-RETICULUM STRESS; PHASE-II TRIAL; IRE1-ALPHA-XBP1; PATHWAY; COLORECTAL-CANCER; SENSITIZES CELLS; DRUG-RESISTANCE; POOR-PROGNOSIS; BREAST-CANCER; GRP78; INHIBITOR;

D O I：

10.1016/j.canlet.2024.216678

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Endoplasmic reticulum (ER) stress and the adaptive response that follows, termed the unfolded protein response (UPR), are crucial molecular mechanisms to maintain cellular integrity by safeguarding proper protein synthesis. Next to being important in protein homeostasis, the UPR is intricate in cell fate decisions such as proliferation, differentiation, and stemness. In the intestine, stem cells are critical in governing epithelial homeostasis and they are the cell of origin of gastrointestinal malignancies. In this review, we will discuss the role of ER stress and the UPR in the gastrointestinal tract, focusing on stem cells and carcinogenesis. Insights in mechanisms that connect ER stress and UPR with stemness and carcinogenesis may broaden our understanding in the development of cancer throughout the gastrointestinal tract and how we can exploit these mechanisms to target these malignancies.

引用

页数：8

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