The healing bitterness of Gentiana lutea L., phytochemistry and biological activities: A systematic review

被引:12
|
作者
Ponticelli, Maria [1 ]
Lela, Ludovica [1 ]
Moles, Mariapia [1 ]
Mangieri, Claudia [1 ]
Bisaccia, Donatella [3 ]
Faraone, Immacolata [1 ,2 ]
Falabella, Roberto [4 ]
Milella, Luigi [1 ]
机构
[1] Univ Basilicata, Dept Sci, Viale ateneo Lucano 10, I-85100 Potenza, Italy
[2] Spinoff Bioactiplant Srl, Viale ateneo Lucano 10, I-85100 Potenza, Italy
[3] Italian Natl Res Council, Water Res Inst, Viale F Blasio 5, I-70123 Bari, Italy
[4] San Carlo Hosp, Urol Unit, Via Potito Petrone, I-85100 Potenza, Italy
关键词
Gentianaceae; Yellow gentian or bitterwort; Systematic review; Bitter compounds; Pharmacological activities; Molecular mechanisms; Gentiana lutea Linn; CENTRAL-NERVOUS-SYSTEM; BINDING PROTEIN 4; TRANSCRIPTIONAL REGULATION; ANTIMICROBIAL ACTIVITY; HELICOBACTER-PYLORI; CELL-PROLIFERATION; DOWN-REGULATION; IN-VITRO; EXTRACTS; INFLAMMATION;
D O I
10.1016/j.phytochem.2022.113518
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Over many years, natural products have been a source of healing agents and have exhibited beneficial uses for treating human diseases. The Gentiana genus is the biggest genus in the Gentianaceae, with over 400 species distributed mainly in alpine zones of temperate countries around the world. Plants in the Gentiana genus have historically been used to treat a wide range of diseases. Still, only in the last years has particular attention been paid to the biological activities of Gentiana lutea Linn., also known as yellow Gentian or bitterwort. Several in vitro/vivo investigations and human interventional trials have demonstrated the promising activity of G. lutea extracts against oxidative stress, microbial infections, inflammation, obesity, atherosclerosis, etc..A systematic approach was performed using Pubmed and Scopus databases to update G. lutea chemistry and activity. Specifically, this systematic review synthesized the major specialized bitter metabolites and the bio-logical activity data obtained from different cell lines, animal models, and human interventional trials. This review aims to the exaltation of G. lutea as a source of bioactive compounds that can prevent and treat several human illnesses.
引用
收藏
页数:27
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