The treatment of hepatitis C virus (HCV) has been a revolution in hepatology. Since the begin-ning of transplantation, liver cirrhosis and hepatocarcinoma on HCV cirrhosis has been the main etiology of liver transplantation. We set out to analyze the impact that C virus treatment has had on liver transplantation. To do so, we divided our cohort into 2 periods, one before virus treat-ment (from 2000-2014) and one after the onset of treatment (2014-2020). Taling into account this differentiation, we analyzed the percentage of patients transplanted for hepatocarcinoma over cirrhotic liver by HCV in both groups. Among the patients transplanted for HCV, we ana-lyzed whether there were differences in hepatocarcinoma recurrences according to their serologic status at the time of transplantation.