X-linked hypophosphatemia, fibroblast growth factor 23 signaling, and craniosynostosis

被引：0

作者：

Grimbly, Chelsey ^{[1
,2
]}

Graf, Daniel ^{[2
,3
]}

Ward, Leanne M. ^{[4
]}

Alexander, R. Todd ^{[1
,2
]}

机构：

[1] Univ Alberta, Dept Pediat, Edmonton Clin Hlth Acad, Edmonton, AB T6G 2R7, Canada

[2] Univ Alberta, Women & Childrens Hlth Res Inst, Edmonton, AB T6G 2R7, Canada

[3] Univ Alberta, Dept Dent & Dent Hyg, Edmonton, AB T6G 2R7, Canada

[4] Univ Ottawa, Childrens Hosp Eastern Ontario, Fac Med, Div Endocrinol & Metab,Dept Pediat, Ottawa, ON K1H 8L1, Canada

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 248卷 / 22期

关键词：

Rickets; phosphate; craniosynostosis; fibroblast growth factor 23; hypophosphatemia; X-linked hypophosphatemia; ALKALINE-PHOSPHATASE; SAGITTAL SYNOSTOSIS; FGF RECEPTOR; RICKETS; BONE; RESISTANT; PHEX; MINERALIZATION; OSTEOPONTIN; GENE;

D O I：

10.1177/15353702231222023

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This review summarizes the current knowledge of fibroblast growth factor 23 signaling in bone and its role in the disease pathology of X-linked hypophosphatemia. Craniosynostosis is an under-recognized complication of X-linked hypophosphatemia. The clinical implications and potential cellular mechanisms invoked by increased fibroblast growth factor 23 signaling causing craniosynostosis are reviewed. Knowledge gaps are identified and provide direction for future clinical and basic science studies.

引用

页码：2175 / 2182

页数：8

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