Substrate-controlled chemoselective synthesis of 1-sulfonylquinazoline-2,4(1H,3H)-diones and 2-sulfonamidobenzonitriles

被引：1
|
作者：
Zhao, Ping [1 ]
Zeng, Qingle [1 ,2 ]
机构：
[1] Chengdu Univ Technol, Coll Mat Chem & Chem Engn, Chengdu, Peoples R China
[2] Chengdu Univ Technol, Coll Mat Chem & Chem Engn, Chengdu 610059, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2023年 / 60卷 / 11期
关键词：
DIVERSITY-ORIENTED SYNTHESIS; NATURAL-PRODUCTS; BIOLOGICAL EVALUATION; HETEROCYCLES; DERIVATIVES; CHEMISTRY; DISCOVERY;
D O I：
10.1002/jhet.4726
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed a diversity-oriented, substrate-controlled, chemoselective synthetic method for a variety of structurally diverse 1-sulfonylquinazoline-2,4(1H,3H)-diones and 2-sulfonamidobenzonitriles. This substrate-controlled synthesis is accomplished through the condensation reaction of 2-(sulfonamido)benzamides with or without an N-methyl group on the amides. The reactions are fulfilled within half an hour at room temperature with solid triphosgene as a convenient condensing agent and pyridine as an acid acceptor. This protocol features easily available starting materials, mild reaction conditions, easy experimental operation, and moderate to excellent yields of products.
引用
收藏
页码：1938 / 1944
页数：7
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