Synthesis and properties of novel type I photosensitizer polycyclic amide

被引：3

作者：

Wang, Kui ^{[1
]}

Ye, Tao ^{[1
]}

Du, Haoyang ^{[1
]}

Jin, Xiangyu ^{[1
]}

Yi, Xiaofen ^{[1
]}

Gao, Huiying ^{[1
]}

Zhang, Yuan ^{[1
]}

Dong, Wei ^{[1
]}

Liu, Shihui ^{[2
]}

Guan, Jing ^{[1
]}

Lin, Feng ^{[1
]}

Xia, Debin ^{[2
,3
]}

机构：

[1] Harbin Med Univ, Coll Pharm, Dept Organ Chem, Harbin, Peoples R China

[2] Harbin Inst Technol, Sch Chem & Chem Engn, MIIT Key Lab Crit Mat Technol New Energy Convers &, Harbin, Peoples R China

[3] Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin, Peoples R China

来源：

NANOSCALE ADVANCES | 2023年 / 5卷 / 14期

基金：

中国国家自然科学基金;

关键词：

PHOTODYNAMIC THERAPY; TUMOR; MODEL;

D O I：

10.1039/d3na00341h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we have designed and synthesized a novel type-I photosensitizer (PhPA) via Rh-catalyzed oxidative cyclization of diacetoxyterephthalamide with alkynes. The photoelectric properties, photosensitivity and photodegradation process of PhPA have been systematically investigated. The remarkable fluorescence quenching effect (& phi;(PL) < 0.01) of PhPA suggests that the intersystem crossing from the singlet excited state to the reactive triplet state is enhanced by the enlarged conjugated backbone. Additionally, the ability of superoxide radical (O-2(-)) generation was confirmed by electron paramagnetic resonance spectroscopy. Finally, the mechanism of PhPA photo-oxidative degradation via the structure of two metabolites is proposed.

引用

页码：3629 / 3633

页数：5

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