Lack of Catalytic and Non-Catalytic Function of PI3 Kinase Gamma in Mice Increases HypoxiaInduced Pulmonary Hypertension

被引：0
|
作者：
Gnatzy-Feik, Leoni
Berghausen, Eva
Vantler, Marius
Rebekka, Mueller
Zierden, Mario
Ghigo, Alessandra
Hirsch, Emilio
Baldus, Stephan
Rosenkranz, Stephan
机构：
来源：
CIRCULATION | 2023年 / 148卷
关键词：
Pulmonary hypertension; Right Ventricular Dysfunction; Hypoxia;
D O I：
10.1161/circ.148.suppl_1.18479
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A18479
引用
收藏
页数：2
相关论文
共 49 条
  • [31] The Unique Non-Catalytic C-Terminus of P37delta-PI3K Adds Proliferative Properties In Vitro and In Vivo
    Ejeskar, Katarina
    Vickes, Oscar
    Kuchipudi, Arunakar
    Wettergren, Yvonne
    Uv, Anne
    Sopasakis, Victoria Rotter
    PLOS ONE, 2015, 10 (05):
  • [32] Non-catalytic subunits, p87 and p101, determine specificity of class IB PI3Kγ enzymes
    Shymanets, Aliaksei
    Prajwal
    Bucher, Kirsten
    Beer-Hammer, Sandra
    Harteneck, Christian
    Nuernberg, Bernd
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2014, 387 : S92 - S92
  • [33] PI3kinase Gamma Kinase Dead Knock-In Mice Are Protected Against Cigarette Smoke-Induced Pulmonary Inflammation
    Wollin, L.
    Gantner, F.
    Maier, U.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183
  • [34] Gβγ recruits heterodimeric phosphatidylinositide 3-kinase γ to the cell membrane through interaction with its non-catalytic p101-subunit
    Brock, C
    Schaefer, M
    Czupalla, C
    Reusch, HP
    Schulz, A
    Nürnberg, B
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2002, 365 : R46 - R46
  • [35] A specific antagonist of the p110-delta catalytic component of PI3 kinase, IC486068, enhances radiation-induced tumor vascular destruction
    Tan, J
    Geng, L
    Hallahan, D
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2004, 60 (01): : S195 - S195
  • [36] Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells
    Folgiero, V.
    Di Carlo, S. E.
    Bon, G.
    Spugnini, E. P.
    Di Benedetto, A.
    Germoni, S.
    Gentileschi, M. Pia
    Accardo, A.
    Milella, M.
    Morelli, G.
    Bossi, G.
    Mottolese, M.
    Falcioni, R.
    CELL DEATH & DISEASE, 2012, 3 : e440 - e440
  • [37] Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells
    V Folgiero
    S E Di Carlo
    G Bon
    E P Spugnini
    A Di Benedetto
    S Germoni
    M Pia Gentileschi
    A Accardo
    M Milella
    G Morelli
    G Bossi
    M Mottolese
    R Falcioni
    Cell Death & Disease, 2012, 3 : e440 - e440
  • [38] The role of non-catalytic p101 and p87 subunits in regulating phosphoinositide 3-kinase γ by Gβγ and H-Ras
    Shymanets, A.
    Ahmadian, M. R.
    Krause, E.
    Wetzker, R.
    Harteneck, C.
    Nuernberg, B.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2012, 385 : 88 - 89
  • [39] Effects of single nucleotide polymorphisms and haplotypes of the protein kinase AMP-activated non-catalytic subunit gamma 3 (PRKAG3) gene on production, meat quality and carcass traits in Italian Large White pigs
    Dall'Olio, Stefania
    Scotti, Emilio
    Costa, Leonardo Nanni
    Fontanesi, Luca
    MEAT SCIENCE, 2018, 136 : 44 - 49
  • [40] Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis
    Hideaki T. Matsubayashi
    Jack Mountain
    Nozomi Takahashi
    Abhijit Deb Roy
    Tony Yao
    Amy F. Peterson
    Cristian Saez Gonzalez
    Ibuki Kawamata
    Takanari Inoue
    Nature Communications, 15
12345