Synthesis of Zr-MOF/rGO-nanocomposites used for spirooxindole scaffolds derivatives

A highly resourceful synthetic strategy has been developed for the production of spirooxindole derivatives employing Zr-MOF/rGO nanocomposites as a heterogeneous catalyst in aqueous ethanol environments. This protocol involves a three-component one-pot reaction comprising isatin, malononitrile, or ethyl cyanoacetate as well as several 1,3-dicarbonyl compounds at room temperature. In addition to achieving synthetic organic product in the reaction mixture, the produced catalyst could be conveniently collected via centrifugation. This approach has several notable advantages, including the use of green solvents, a short reaction time, operational simplicity, simple reaction conditions, and a high product yield. Furthermore, the resulting Zr-MOF/rGOnanocatalyst exhibits advantages such as outstanding stability, high activity, and reusability for up to five cycles without significant loss.