Copper-Catalyzed Annulation of O-Acyl Oximes with Cyclic 1,3-Diones for the Synthesis of 7,8-Dihydroindolizin-5(6H)-ones and Cyclohexanone-Fused Furans

被引：10

作者：

Yang, Hai-Tao ^{[1
]}

Zhou, Su-Qing ^{[1
]}

Chen, Dan-Mei ^{[1
]}

Hu, Zi-Jun ^{[1
]}

Qiang, Xiao-Qi ^{[1
]}

Song, Xiao-Qing ^{[1
]}

Tan, Sheng ^{[1
]}

Jiang, Wei-Hua ^{[1
]}

Sun, Yong-Qiang ^{[2
]}

Miao, Chun-Bao ^{[1
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab ofAdvanced Catalyt Mat & Technol, Jiangsu Prov Key Lab Fine Petrochem Engn, Changzhou 213164, Jiangsu, Peoples R China

[2] Changzhou Siyao Pharmaceut Co Ltd, Changzhou 213018, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2023年

关键词：

3-COMPONENT CASCADE ANNULATION; ACETATES; 1-ACYL-1H-PYRROLES; CYCLIZATIONS; HETEROCYCLES; ALKALOIDS; INDOLES;

D O I：

10.1021/acs.orglett.3c00003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed annulation of O-acyl oximes with cyclic 1,3-diones has been developed for the concise synthesis of 7,8-dihydroindolizin-5(6H)-ones and cyclohexanone-fused furans through the substituent-controlled selective radical coupling process. 2-Alkyl cyclic 1,3-diones undergo C-C radical coupling, while 2-unsubstituted cyclic 1,3-diones undergo C-O radical coupling.

引用

页码：838 / 842

页数：5

共 14 条

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