Copper-Catalyzed Annulation of O-Acyl Oximes with Cyclic 1,3-Diones for the Synthesis of 7,8-Dihydroindolizin-5(6H)-ones and Cyclohexanone-Fused Furans

被引:10
|
作者
Yang, Hai-Tao [1 ]
Zhou, Su-Qing [1 ]
Chen, Dan-Mei [1 ]
Hu, Zi-Jun [1 ]
Qiang, Xiao-Qi [1 ]
Song, Xiao-Qing [1 ]
Tan, Sheng [1 ]
Jiang, Wei-Hua [1 ]
Sun, Yong-Qiang [2 ]
Miao, Chun-Bao [1 ]
机构
[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab ofAdvanced Catalyt Mat & Technol, Jiangsu Prov Key Lab Fine Petrochem Engn, Changzhou 213164, Jiangsu, Peoples R China
[2] Changzhou Siyao Pharmaceut Co Ltd, Changzhou 213018, Jiangsu, Peoples R China
关键词
3-COMPONENT CASCADE ANNULATION; ACETATES; 1-ACYL-1H-PYRROLES; CYCLIZATIONS; HETEROCYCLES; ALKALOIDS; INDOLES;
D O I
10.1021/acs.orglett.3c00003
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A copper-catalyzed annulation of O-acyl oximes with cyclic 1,3-diones has been developed for the concise synthesis of 7,8-dihydroindolizin-5(6H)-ones and cyclohexanone-fused furans through the substituent-controlled selective radical coupling process. 2-Alkyl cyclic 1,3-diones undergo C-C radical coupling, while 2-unsubstituted cyclic 1,3-diones undergo C-O radical coupling.
引用
收藏
页码:838 / 842
页数:5
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