Experimental drugs for the prevention or treatment of sensorineural hearing loss

被引：3

作者：

Kempfle, Judith S. ^{[1
,2
,3
,4
]}

Jung, David H. ^{[1
,2
]}

机构：

[1] Massachusetts Eye & Ear, Dept Otolaryngol, Boston, MA USA

[2] Harvard Med Sch, Dept Otolaryngol Head & Neck Surg, Boston, MA USA

[3] UMass Mem Med Ctr, Dept Otolaryngol, Worcester, MA USA

[4] Univ Massachusetts, Dept Otolaryngol Head & Neck Surg, Med Sch, Worcester, MA USA

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2023年 / 32卷 / 07期

关键词：

inner ear therapeutics; otoprotection; regeneration; small molecules; synaptopathy; sensorineural hearing loss; HAIR-CELL REGENERATION; SPIRAL-GANGLION NEURONS; AUDITORY-NERVE FIBERS; INNER-EAR; COCHLEAR NEUROPATHY; GENTAMICIN TOXICITY; MAMMALIAN COCHLEA; ATOH1; EXPRESSION; SUPPORTING CELLS; RISK-FACTORS;

D O I：

10.1080/13543784.2023.2242253

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction Sensorineural hearing loss results in irreversible loss of inner ear hair cells and spiral ganglion neurons. Reduced sound detection and speech discrimination can span all ages, and sensorineural hearing rehabilitation is limited to amplification with hearing aids or cochlear implants. Recent insights into experimental drug treatments for inner ear regeneration and otoprotection have paved the way for clinical trials in order to restore a more physiological hearing experience. Paired with the development of innovative minimally invasive approaches for drug delivery to the inner ear, new, emerging treatments for hearing protection and restoration are within reach. Areas covered This expert opinion provides an overview of the latest experimental drug therapies to protect from and to restore sensorineural hearing loss. Expert opinion The degree and type of cellular damage to the cochlea, the responsiveness of remaining, endogenous cells to regenerative treatments, and the duration of drug availability within cochlear fluids will determine the success of hearing protection or restoration.

引用

页码：643 / 654

页数：12

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