Translational opportunities of single-cell biology in atherosclerosis

被引：36

作者：

de Winther, Menno P. J. ^{[1
]}

Back, Magnus ^{[2
,3
,4
]}

Evans, Paul ^{[5
,6
]}

Gomez, Delphine ^{[7
]}

Goncalves, Isabel ^{[8
,9
]}

Jorgensen, Helle F. ^{[10
]}

Koenen, Rory R. ^{[11
]}

Lutgens, Esther ^{[12
,13
,14
]}

Norata, Giuseppe Danilo ^{[15
,16
]}

Osto, Elena ^{[17
,18
,19
]}

Dib, Lea ^{[20
]}

Simons, Michael ^{[21
,22
,23
]}

Stellos, Konstantinos ^{[24
]}

Yla-Herttuala, Seppo ^{[25
,26
]}

Winkels, Holger ^{[27
,28
]}

Bochaton-Piallat, Marie-Luce ^{[29
]}

Monaco, Claudia ^{[20
]}

机构：

[1] Amsterdam UMC Locat Univ Amsterdam, Dept Med Biochem, Amsterdam Infect & Immun, Amsterdam Cardiovasc Sci, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[2] Karolinska Inst, Translat Cardiol, Stockholm, Sweden

[3] Karolinska Univ Hosp, Stockholm, Sweden

[4] Univ Lorraine, Nancy Univ Hosp, INSERM U1116, Nancy, France

[5] Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, INSIGNEO, Sheffield, S Yorkshire, England

[6] Univ Sheffield, Bateson Ctr, Sheffield, S Yorkshire, England

[7] Univ Pittsburgh, Dept Med, Div Cardiol, Heart Lung Blood & Vasc Med Inst, Pittsburgh, PA USA

[8] Lund Univ, Cardiovasc Res Translat Studies, Clin Sci, Malmo, Sweden

[9] Skane Univ Hosp, Dept Cardiol, Malmo, Sweden

[10] Univ Cambridge, Dept Med, Cardioresp Med Sect, Hills Rd, Cambridge CB2 0QQ, England

[11] Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Biochem, Maastricht, Netherlands

[12] Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent IPEK, Munich, Germany

[13] German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany

[14] Mayo Clin, Cardiovasc Med, Expt CardioVasc Immunol Lab, Rochester, MN USA

[15] Univ Milan, Dept Excellence Pharmacol & Biomol Sci, Milan, Italy

[16] Bassini Hosp, Ctr Study Atherosclerosis, Cinisello Balsamo, SISA, Milan, Italy

[17] Univ Hosp, Inst Clin Chem, Heart Ctr, Zurich, Switzerland

[18] Univ Hosp, Dept Cardiol, Heart Ctr, Zurich, Switzerland

[19] Univ Zurich, Zurich, Switzerland

[20] Univ Oxford, Kennedy Inst Rheumatol, NDORMS, Roosevelt Dr, Oxford OX3 7FY, England

[21] Yale Univ, Dept Internal Med, 300 George St, New Haven, CT 06511 USA

[22] Yale Univ, Dept Cell Biol, 300 George St, New Haven, CT 06511 USA

[23] Yale Cardiovasc Res Ctr, 300 George St, New Haven, CT 06511 USA

[24] Heidelberg Univ, Med Fac Mannheim, European Ctr Angiosci, Mannheim, Germany

[25] Univ Eastern Finland, AI Virtanen Inst, Kuopio, Finland

[26] Kuopio Univ Hosp, Heart Ctr, Kuopio, Finland

[27] Univ Cologne, Fac Med, Dept Internal Med 3, Div Cardiol, Kerpener Str 62, D-50937 Cologne, Germany

[28] Univ Hosp Cologne, Kerpener Str 62, D-50937 Cologne, Germany

[29] Univ Geneva, Fac Med, Dept Pathol & Immunol, Geneva, Switzerland

来源：

EUROPEAN HEART JOURNAL | 2023年 / 44卷 / 14期

关键词：

Single-cell biology; Atherosclerosis; Macrophage; Lymphocyte; Smooth muscle cell; Endothelial cell; SMOOTH-MUSCLE-CELLS; MACROPHAGE-LIKE CELLS; MESENCHYMAL TRANSITION; GENE-EXPRESSION; BETA; CLASSIFICATION; IMMUNITY; SUBSETS;

D O I：

10.1093/eurheartj/ehac686

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease development and direct towards new therapeutic strategies. These approaches have begun to revolutionize atherosclerosis pathology and redraw our understanding of disease development. This review discusses the state-of-the-art of single-cell analysis of atherosclerotic plaques, with a particular focus on human lesions, and presents the current resolution of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. Opportunities and pitfalls of current technologies as well as the clinical impact of single-cell technologies in CVD patient care are highlighted, advocating for multidisciplinary and international collaborative efforts to join the cellular dots of CVD.

引用

页码：1216 / 1230

页数：15

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