Lewis Acid Promoted Deprotection of Benzylidene Acetals and p-Methoxybenzyl Ethers with Mercaptoacid Acid as Scavenger

被引：2

作者：

Greve, Rasmus D. ^{[1
]}

Jensen, Henrik H. ^{[1
]}

机构：

[1] Aarhus Univ, DK-8000 Aarhus, Denmark

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 20期

关键词：

BY-PRODUCTS; CLEAVAGE; REMOVAL; NAP; PHASE;

D O I：

10.1021/acs.orglett.3c00958

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We demonstrate a new and high-yieldingmethod for removalof benzylideneacetals and para-methoxybenzyl ethers under catalyticconditions (BF3:OEt2 orFeCl(3), 10mol%) with mercaptoacetic acid as a scavenger. The reaction coproductsare converted to water-soluble molecules, which can be removed byaqueous extraction, thereby bypassing the need for chromatographicpurification. The reaction was demonstrated on both multimilligramand multigram scale.

引用

页码：3628 / 3632

页数：5

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