Direct oxidation of 3-picoline (3-methyl-pyridine) to nicotinic acid with pure HNO3

被引：1
|
作者：
Gomes, Eliezer L. [1 ]
de Freitas, David A. [2 ]
Condotta, Rodrigo [3 ]
Poco, Joao Guilherme R. [3 ]
机构：
[1] Univ Fed Sao Paulo UNIFESP, Dept Engn Quim, Diadema, SP, Brazil
[2] Inst Pesquisas Tecnol Estado Sao Paulo IPT, Sao Paulo, SP, Brazil
[3] Ctr Univ FEI, Dept Engn Quim, Sao Bernardo Do Campo, SP, Brazil
来源：
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING | 2024年 / 41卷 / 04期
关键词：
Nicotinic acid; 3-methylpyridine; HNO3; oxidation;
D O I：
10.1007/s43153-023-00369-0
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Nicotinic acid (NA) was synthesized by directly oxidizing 3-methylpyridine (3MP) with nitric acid. The reaction was performed in an instrumented PARR reactor. The effect of temperature (165 to 195 & DEG;C) and the molar composition of the initial reactive mixture were studied. Molar conversions of 3-methylpyridine ranged from 36 to 90%, with a yield of NA ranging from 31 to 62%. Better selectivities occur at low-time reactions and low conversion rates. At the same time, the HNO3 excess and temperature considerably affect 3MP conversion rate and NA yield rather than selectivity, especially at 180 & DEG;C, whereas an invariable selectivity of 80% was observed.
引用
收藏
页码：1021 / 1033
页数：13
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