Single-Cell Metabolic Profiling Integrated with Extracellular Vesicle Analysis Reveals Novel Metabolic Vulnerabilities and Prognostic Biomarkers in Acute Myeloid Leukemia

被引：0
|
作者：
Forte, Dorian [1 ]
Maltoni, Filippo [1 ]
Bruno, Samantha [1 ]
Garcia-Gonzalez, Paulina [2 ]
Cristiano, Gianluca [1 ]
Sartor, Chiara [1 ]
Soverini, Simona [1 ]
Catani, Lucia [1 ,3 ]
Arguello, Rafael Jose [2 ]
Cavo, Michele [1 ,3 ]
Curti, Antonio [3 ]
机构：
[1] Univ Bologna, Inst Hematol L & A Seragnoli, Dept Med & Surg Sci, Bologna, Italy
[2] Aix Marseille Univ, CNRS, Ctr Immunol Marseille Luminy, INSERM,CIML, Marseille, France
[3] IRCCS Azienda Osped Univ Bologna, Ist Ematol Seragnoli, Bologna, Italy
来源：
BLOOD | 2023年 / 142卷
关键词：
D O I：
10.1182/blood-2023-185909
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：4
相关论文
共 50 条
  • [41] SINGLE-CELL PROFILING OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA REVEALS A GRADUAL TRANSITION FROM PRE-LEUKEMIA TO LEUKEMIA
    Tur, Steven
    Mokthari, Zeinab
    Brand, Marjorie
    Fallahi, Magid
    Jalan, Manisha
    Zhang, Qingzhou
    EXPERIMENTAL HEMATOLOGY, 2022, 111 : S149 - S149
  • [42] Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype
    Leppa, Aino-Maija
    Grimes, Karen
    Jeong, Hyobin
    Huang, Frank Y.
    Andrades, Alvaro
    Waclawiczek, Alexander
    Boch, Tobias
    Jauch, Anna
    Renders, Simon
    Stelmach, Patrick
    Mueller-Tidow, Carsten
    Karpova, Darja
    Sohn, Markus
    Gruenschlaeger, Florian
    Hasenfeld, Patrick
    Benito Garagorri, Eva
    Thiel, Vera
    Dolnik, Anna
    Rodriguez-Martin, Bernardo
    Bullinger, Lars
    Mrozek, Krzysztof
    Eisfeld, Ann-Kathrin
    Kraemer, Alwin
    Sanders, Ashley D.
    Korbel, Jan O.
    Trumpp, Andreas
    NATURE GENETICS, 2024, : 2790 - 2803
  • [43] Single-Cell DNA Sequencing and Immunophenotypic Profiling to Track Clonal Evolution in an Acute Myeloid Leukemia Patient
    Garcia-Alvarez, Maria
    Yeguas, Ana
    Jimenez, Cristina
    Medina-Herrera, Alejandro
    Gonzalez-Calle, Veronica
    Hernandez-Ruano, Montserrat
    Maldonado, Rebeca
    Aires, Irene
    Casquero, Cristina
    Sanchez-Villares, Inmaculada
    Balanzategui, Ana
    Sarasquete, Maria Eugenia
    Alcoceba, Miguel
    Vidriales, Maria Belen
    Gonzalez-Diaz, Marcos
    Garcia-Sanz, Ramon
    Chillon, Maria Carmen
    BIOMEDICINES, 2024, 12 (01)
  • [44] Single-Cell Mass Cytometry Reveals Phenotypic and Functional Heterogeneity In Acute Myeloid Leukemia At Diagnosis and In Remission
    Han, Lina
    Zeng, Zhihong
    Qiu, Peng
    Jorgensen, Jeffrey L.
    Mak, Duncan H.
    Burks, Jared K.
    McQueen, Teresa
    Ravandi, Farhad
    Roboz, Gail J.
    Kantarjian, Hagop M.
    Kornblau, Steven M.
    Guzman, Monica L.
    Andreeff, Michael
    Konopleva, Marina
    BLOOD, 2013, 122 (21)
  • [45] INTRACELLULAR AND SYSTEMIC METABOLIC PROFILING OF ACUTE MYELOID LEUKEMIA IMPROVES GENOMIC CLASSIFICATION AND SUGGESTS NOVEL THERAPEUTIC TARGETS
    Simonetti, G.
    Padella, A.
    Mengucci, C.
    Fonzi, E.
    Picone, G.
    Pazzaglia, M.
    Perricone, M.
    Fontana, M. C.
    Bruno, S.
    Bochic-Chio, M. T.
    Franchini, E.
    Nanni, J.
    Marconi, G.
    do Valle, I. F.
    De Tommaso, R.
    Ferrari, A.
    Ghetti, M.
    Napolitano, R.
    Papayannidis, C.
    Cerchione, C.
    Ottaviani, E.
    Castellani, G.
    Remondini, D.
    Capozzi, F.
    Martinelli, G.
    HAEMATOLOGICA, 2019, 104 : 51 - 51
  • [46] Single-Cell Phospho-Profiling in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia Reveals Signaling Differences in Cytogenetic and Prognostic Subgroups
    Queudeville, Manon
    Eckhoff, Sarah M.
    Debatin, Klaus-Michael
    Meyer, Lueder H.
    BLOOD, 2009, 114 (22) : 1040 - 1040
  • [47] Single-cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia
    Robinson, Troy M.
    Bowman, Robert L.
    Persaud, Sonali
    Liu, Ying
    Neigenfind, Rosemary
    Gao, Qi
    Zhang, Jingping
    Sun, Xiaotian
    Miles, Linde A.
    Cai, Sheng F.
    Sciambi, Adam
    Llanso, Aaron
    Famulare, Christopher
    Goldberg, Aaron
    Dogan, Ahmet
    Roshal, Mikhail
    Levine, Ross L.
    Xiao, Wenbin
    SCIENCE ADVANCES, 2023, 9 (38)
  • [48] Single-Cell RNA Sequencing Analysis Reveals Metabolic Changes in Epithelial Glycosphingolipids and Establishes a Prognostic Risk Model for Pancreatic Cancer
    Ba, Qinwen
    Wang, Xiong
    Hu, Hui
    Lu, Yanjun
    DIAGNOSTICS, 2024, 14 (11)
  • [49] Comprehensive single-cell analysis of Sezary syndrome reveals novel expression and therapeutic biomarkers
    Borcherding, N.
    Henderson, N.
    Ortolan, L.
    Liu, V.
    Link, B.
    Mangold, A.
    Jabbari, A.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2021, 141 (05) : S12 - S12
  • [50] Leukemic Stem Cell Responses to Induction Chemotherapy Identify Novel Prognostic Biomarkers in Acute Myeloid Leukemia
    Raciti, Patricia
    Hu, Wenhuo
    Stranahan, Alec
    Woolthuis, Carolien
    Devlin, Sean
    Park, Christopher
    LABORATORY INVESTIGATION, 2016, 96 : 371A - 371A
12345