Proposal of novel staging system CNM (Crohn's primary site, nodes, mesentery) to predict postoperative recurrence of Crohn's disease

被引:1
|
作者
Rao, Guduru Venkat [1 ]
Pal, Partha [2 ]
Sekaran, Anuradha [3 ]
Rebala, Pradeep [1 ]
Tandan, Manu [2 ]
Reddy, D. Nageshwar [2 ]
机构
[1] Asian Inst Gastroenterol, Dept Surg Gastroenterol, Hyderabad, India
[2] Asian Inst Gastroenterol, Dept Med Gastroenterol, Hyderabad, India
[3] Asian Inst Gastroenterol, Dept Pathol, Hyderabad, India
关键词
Crohn disease; Recurrence; Ileocecal resection; Histology; Pathology; MYENTERIC PLEXITIS; ENDOSCOPIC RECURRENCE; ILEOCECAL RESECTION; CLINICAL RECURRENCE; RISK-FACTOR; GRANULOMAS; CONSENSUS; MARGINS; INFLAMMATION; BOWEL;
D O I
10.5217/ir.2022.00045
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
After oncologic resection, histological grading and staging of the tumor give important prognostic information about the future risk of recurrence and hence influence the subsequent management plan. Several studies and their meta-analysis have shown that various histological features (e.g., microscopic positive resection margins, plexitis, granuloma, mesenteric inflammatory activity) can predict postoperative clinical/endoscopic/surgical recurrence after resection in Crohn's disease (CD). Inclusion of mesentery in surgical resection specimens has been shown to reduce surgical recurrence after ileocolonic resection in CD. However, there is no uniform histopathological staging system for risk stratification in postoperative CD to systematically predict postoperative recurrence. This is because the prediction to date is based on clinical characteristics (smoking status, disease phenotype, surgical history). Histopathological predictors are still not adopted in routine clinical practice due to the lack of a uniform staging system, heterogeneity of published studies and lack of standardized definition of histological features. In this article, we attempted to incorporate all such histological features in a single histological staging system CNM (Crohn's primary site [resection margin positivity, plexitis, granuloma, depth of infiltration], nodes [presence of granuloma], mesentery [involved or not]) in surgical resection specimen in CD. The proposed CNM classification would help to enable systematic reporting, design future clinical trials, stratify postoperative recurrence risk and choose appropriate postoperative prophylaxis.
引用
收藏
页码:196 / 204
页数:9
相关论文
共 50 条
  • [21] The role of the mesentery in reducing recurrence after surgery in Crohn’s disease
    Dakshitha Wickramasinghe
    Janindra Warusavitarne
    Updates in Surgery, 2019, 71 : 11 - 12
  • [22] Endoscopic Prediction of Crohn's Disease Postoperative Recurrence
    De Cruz, Peter
    Hamilton, Amy L.
    Burrell, Kathryn J.
    Gorelik, Alexandra
    Liew, Danny
    Kamm, Michael A.
    INFLAMMATORY BOWEL DISEASES, 2022, 28 (05) : 680 - 688
  • [23] Prevention of postoperative recurrence in Crohn's disease.
    D'Haens G.
    Current Gastroenterology Reports, 1999, 1 (6) : 476 - 481
  • [24] Azathioprine for prevention of postoperative recurrence in Crohn's disease
    Travis, S
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2001, 13 (11) : 1277 - 1279
  • [25] Postoperative Crohn's disease recurrence:: A practical approach
    Nos, Pilar
    Domenech, Eugeni
    WORLD JOURNAL OF GASTROENTEROLOGY, 2008, 14 (36) : 5540 - 5548
  • [26] Pharmacological Prevention of Postoperative Recurrence in Crohn's Disease
    Vuitton, Lucine
    Peyrin-Biroulet, Laurent
    DRUGS, 2020, 80 (04) : 385 - 399
  • [27] Postoperative Recurrence of Crohn's Disease: The Beginning of the End?
    Sorrentino, Dario
    Paviotti, Alberto
    GASTROENTEROLOGY, 2009, 137 (03) : 1181 - 1182
  • [28] Strategies for the prevention of postoperative recurrence of Crohn's disease
    Yamamoto, T.
    Watanabe, T.
    COLORECTAL DISEASE, 2013, 15 (12) : 1471 - 1480
  • [29] Adalimumab in the Prevention of Postoperative Recurrence of Crohn's Disease
    Fernandez-Blanco, Ignacio
    Monturiol, J.
    Martinez, Barbara
    Cara, Carlos
    Taxonera, Carlos
    GASTROENTEROLOGY, 2010, 138 (05) : S692 - S692
  • [30] Postoperative recurrence prophylaxis in Crohn's disease: an update
    Rutgeerts, PJ
    IBD AND SALICYLATES - 3, 1998, 20 (01): : 49 - 55