The engineering and application of extracellular matrix hydrogels: a review

被引：19

作者：

Zhang, Yunting ^{[1
,2
]}

Xu, Yihua ^{[1
]}

Gao, Jianqing ^{[1
,2
,3
]}

机构：

[1] Zhejiang Univ, Inst Pharmaceut, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China

[2] Zhejiang Univ, Jinhua Inst, Jinhua 321002, Peoples R China

[3] Jiangsu Engn Res Ctr New Type External & Transderm, Changzhou 213149, Peoples R China

来源：

BIOMATERIALS SCIENCE | 2023年 / 11卷 / 11期

关键词：

ECM HYDROGEL; SILVER NANOPARTICLES; THIOGLYCOLIC ACID; TISSUE-REPAIR; STEM; DECELLULARIZATION; BIOMATERIALS; REGENERATION; DRESSINGS; PERFUSION;

D O I：

10.1039/d3bm00183k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

This review provides an overview of the engineering and application of extracellular matrix (ECM) hydrogels. ECM hydrogels are attractive materials for tissue engineering and regenerative medicine due to their unique ability to mimic the natural ECM of various tissues. The review discusses the different methods used for the preparation of ECM hydrogels and the factors that influence their properties. This review is the summary of three engineering approaches for ECM hydrogels, which are chemical modification of the gel scaffold (chemical modification), addition of active substances to the scaffold (physical addition), and gene editing of the ECM donor (biological modification). Additionally, it covers the various applications of ECM hydrogels in tissue restoration, organoid culturing, and 3D microenvironment reconstruction. The review concludes with a discussion of the advantages, limitations, and future directions of ECM hydrogel research and development. Overall, this review highlights the potential of ECM hydrogels as a promising biomaterial for a range of biomedical applications and provides fresh perspectives for ECM hydrogels to continue their clinical development.

引用

页码：3784 / 3799

页数：16

共 50 条

[41] Hyaluronic Acid Click Hydrogels Emulate the Extracellular Matrix
Owen, Shawn C.
Fisher, Stephanie A.
Tam, Roger Y.
Nimmo, Chelsea M.
Shoichet, Molly S.
[J]. LANGMUIR, 2013, 29 (24) : 7393 - 7400
[42] The design of reversible hydrogels to capture extracellular matrix dynamics
Rosales, Adrianne M.
Anseth, Kristi S.
[J]. NATURE REVIEWS MATERIALS, 2016, 1 (02):
[43] A Review on the Biomaterials Fabricated for Cardiac Tissue Engineering Using Decellularized Extracellular Matrix
John, Shiny Punalur
Nagarajan, Ramamurthy
[J]. REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE, 2024,
[44] Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations
Liu, Juan
Song, Qingru
Yin, Wenzhen
Li, Chen
An, Ni
Le, Yinpeng
Wang, Qi
Feng, Yutian
Hu, Yuelei
Wang, Yunfang
[J]. EXPLORATION, 2024,
[45] The design of reversible hydrogels to capture extracellular matrix dynamics
Adrianne M. Rosales
Kristi S. Anseth
[J]. Nature Reviews Materials, 1
[46] Nanofunctionalised Hydrogels Mimicking In Vitro Cartilage Extracellular Matrix
Gentile, P.
Ghione, C.
[J]. TISSUE ENGINEERING PART A, 2015, 21 : S322 - S322
[47] Development and Characterization of Decellularized Lung Extracellular Matrix Hydrogels
Ozdinc, Sevval
Sarica, Sevgi
Ozkan, Sena N.
Yangin, Kardelen
Kusoglu, Alican
Dansik, Asli
Karaoglu, Ismail C.
Kizilel, Seda
Ozturk, Ece
[J]. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2023, (202):
[48] Hydrogels to Recapture Extracellular Matrix Cues That Regulate Vascularization
Song, Jiyeon
Gerecht, Sharon
[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2023, 43 (08) : E291 - E302
[49] Development potential of extracellular matrix hydrogels as hemostatic materials
Cai, Dan
Weng, Wei
[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2023, 11
[50] Extracellular matrix and tissue engineering applications
Fernandes, Hugo
Moroni, Lorenzo
van Blitterswijk, Clemens
de Boer, Jan
[J]. JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (31) : 5474 - 5484

← 1 2 3 4 5 →