Introduction: Microtubule-associated tumor suppressor 1 (MTUS1) is a novel tumor suppressor protein involved in cell proliferation, migration, and tumor growth. MTUS1 is thought to be downregulated in various human cancers and associated with poor prognosis. We evaluated the clinicopathologic significance and prognostic value of MTUS1 in colorectal adenocarcinoma. Methods: Immunohistochemical staining for MTUS1 was performed on tissue microarrays of 393 colorectal adenocarcinoma cases, and MTUS1 staining was classified into high- and low-expression groups. Then, we investigated the correlations between MTUS1 protein expression and various clinicopathological parameters and patient survival. Results: MTUS1 protein was expressed at various grade levels in the cytoplasm of tumor cells, which showed loss or decreased expression of MTUS1. A total of 253 cases (64.4%) were classified into the low MTUS1 protein expression group and 140 cases (35.6%) into the high MTUS1 expression group. A low level of MTUS1 protein significantly correlated with tumor size (p = 0.047), histological grade (p < 0.001), lymphovascular invasion (p < 0.001), perineural invasion (p = 0.047), and lymph node metastasis (p < 0.001). Survival analyses showed that patients with low MTUS1 protein expression had worse overall survival (p = 0.007, log-rank test) and worse recurrence-free survival (p = 0.019, log-rank test) than those with high MTUS1 expression. Conclusions: Low MTUS1 protein expression is associated with adverse clinicopathological characteristics and poor survival outcomes in patients with colorectal adenocarcinoma. These results suggest that MTUS1 functions as a tumor suppressor in colorectal adenocarcinoma and could be a potential prognostic biomarker.
机构:
King Abdulaziz Univ, Fac Med, Dept Pathol, POB 80205, Jeddah 21589, Saudi ArabiaKing Abdulaziz Univ, Fac Med, Dept Pathol, POB 80205, Jeddah 21589, Saudi Arabia
机构:
Shanghai Resp Res Inst, Shanghai, Peoples R ChinaShanghai Resp Res Inst, Shanghai, Peoples R China
Gong, X.
Zhou, J.
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Shanghai Resp Res Inst, Shanghai, Peoples R ChinaShanghai Resp Res Inst, Shanghai, Peoples R China
Zhou, J.
Song, Y.
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Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R ChinaShanghai Resp Res Inst, Shanghai, Peoples R China
Song, Y.
Bai, C.
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Shanghai Resp Res Inst, Shanghai, Peoples R China
Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R ChinaShanghai Resp Res Inst, Shanghai, Peoples R China
机构:
Fourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R ChinaFourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R China
Chu, Dake
Li, Yunming
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Fourth Mil Med Univ, Dept Hlth Stat, Xian 710032, Shaanxi Prov, Peoples R ChinaFourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R China
Li, Yunming
Wang, Weizhong
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Fourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R ChinaFourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R China
Wang, Weizhong
Zhao, Qingchuan
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Fourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R ChinaFourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R China
Zhao, Qingchuan
Li, Jipeng
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Fourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R ChinaFourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R China
Li, Jipeng
Lu, Yuanyuan
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Fourth Mil Med Univ, State Key Lab Canc Biol, Inst Digest Dis, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R ChinaFourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R China
Lu, Yuanyuan
Li, Mengbin
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Fourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R ChinaFourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R China
Li, Mengbin
Dong, Guanglong
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Fourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R ChinaFourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R China
Dong, Guanglong
Zhang, Hongwei
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Fourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R ChinaFourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R China
Zhang, Hongwei
Xie, Huahong
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Fourth Mil Med Univ, State Key Lab Canc Biol, Inst Digest Dis, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R ChinaFourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R China
Xie, Huahong
Ji, Gang
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Fourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R ChinaFourth Mil Med Univ, State Key Lab Canc Biol, Dept Gastrointestinal Surg, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R China
机构:The Fourth Military Medical University,State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases
Dake Chu
Yunming Li
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h-index: 0
机构:The Fourth Military Medical University,State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases
Yunming Li
Weizhong Wang
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机构:The Fourth Military Medical University,State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases
Weizhong Wang
Qingchuan Zhao
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机构:The Fourth Military Medical University,State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases
Qingchuan Zhao
Jipeng Li
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机构:The Fourth Military Medical University,State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases
Jipeng Li
Yuanyuan Lu
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机构:The Fourth Military Medical University,State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases
Yuanyuan Lu
Mengbin Li
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机构:The Fourth Military Medical University,State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases
Mengbin Li
Guanglong Dong
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机构:The Fourth Military Medical University,State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases
Guanglong Dong
Hongwei Zhang
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机构:The Fourth Military Medical University,State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases
Hongwei Zhang
Huahong Xie
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机构:The Fourth Military Medical University,State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases
Huahong Xie
Gang Ji
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机构:The Fourth Military Medical University,State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases
Gang Ji
Annals of Surgical Oncology,
2010,
17
: 1337
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1342