Low MTUS1 Protein Expression Is Associated with Poor Survival in Patients with Colorectal Adenocarcinoma

被引:0
|
作者
Park, Hosub [1 ]
Jee, Seungyun [1 ]
Son, Hwangkyu [1 ]
Cha, Hyebin [1 ]
Bang, Seongsik [1 ]
Ahn, Byung Kyu [2 ]
Myung, Jaekyung [1 ]
Paik, Seungsam [1 ]
Kim, Hyunsung [1 ]
机构
[1] Hanyang Univ, Hanyang Univ Hosp, Coll Med, Dept Pathol, Seoul 04763, South Korea
[2] Hanyang Univ, Hanyang Univ Hosp, Coll Med, Dept Surg, Seoul 04763, South Korea
关键词
microtubule-associated tumor suppressor 1 (MTUS1); prognosis; colorectal adenocarcinoma; TUMOR-SUPPRESSOR; PROGNOSIS; CANCER;
D O I
10.3390/diagnostics13061140
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Microtubule-associated tumor suppressor 1 (MTUS1) is a novel tumor suppressor protein involved in cell proliferation, migration, and tumor growth. MTUS1 is thought to be downregulated in various human cancers and associated with poor prognosis. We evaluated the clinicopathologic significance and prognostic value of MTUS1 in colorectal adenocarcinoma. Methods: Immunohistochemical staining for MTUS1 was performed on tissue microarrays of 393 colorectal adenocarcinoma cases, and MTUS1 staining was classified into high- and low-expression groups. Then, we investigated the correlations between MTUS1 protein expression and various clinicopathological parameters and patient survival. Results: MTUS1 protein was expressed at various grade levels in the cytoplasm of tumor cells, which showed loss or decreased expression of MTUS1. A total of 253 cases (64.4%) were classified into the low MTUS1 protein expression group and 140 cases (35.6%) into the high MTUS1 expression group. A low level of MTUS1 protein significantly correlated with tumor size (p = 0.047), histological grade (p < 0.001), lymphovascular invasion (p < 0.001), perineural invasion (p = 0.047), and lymph node metastasis (p < 0.001). Survival analyses showed that patients with low MTUS1 protein expression had worse overall survival (p = 0.007, log-rank test) and worse recurrence-free survival (p = 0.019, log-rank test) than those with high MTUS1 expression. Conclusions: Low MTUS1 protein expression is associated with adverse clinicopathological characteristics and poor survival outcomes in patients with colorectal adenocarcinoma. These results suggest that MTUS1 functions as a tumor suppressor in colorectal adenocarcinoma and could be a potential prognostic biomarker.
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页数:10
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