MR imaging and outcome in neonatal HIBD models are correlated with sex: the value of diffusion tensor MR imaging and diffusion kurtosis MR imaging

被引:1
|
作者
Bao, Jieaoxue [1 ,2 ]
Zhang, Xiaoan [1 ,2 ]
Zhao, Xin [1 ,2 ]
机构
[1] Zhengzhou Univ, Affiliated Hosp 3, Dept Imaging, Zhengzhou, Peoples R China
[2] Henan Int Joint Lab Neuroimaging, Zhengzhou, Peoples R China
基金
中国国家自然科学基金;
关键词
diffusion kurtosis imaging; neonate; hypoxic-ischemic; neurobehavioral deficiency; sex difference; HYPOXIC-ISCHEMIC ENCEPHALOPATHY; TRAUMATIC BRAIN-INJURY; RAT MODEL; MICROSTRUCTURAL ALTERATIONS; GENDER DIFFERENCES; MEAN DIFFUSIVITY; MEMORY DEFICITS; WATER DIFFUSION; STROKE; DAMAGE;
D O I
10.3389/fnins.2023.1234049
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
ObjectiveHypoxic-ischemic encephalopathy can lead to lifelong morbidity and premature death in full-term newborns. Here, we aimed to determine the efficacy of diffusion kurtosis (DK) [mean kurtosis (MK)] and diffusion tensor (DT) [fractional anisotropy (FA), mean diffusion (MD), axial diffusion (AD), and radial diffusion (RD)] parameters for the early diagnosis of early brain histopathological changes and the prediction of neurodegenerative events in a full-term neonatal hypoxic-ischemic brain injury (HIBD) rat model.MethodsThe HIBD model was generated in postnatal day 7 Sprague-Dawley rats to assess the changes in DK and DT parameters in 10 specific brain structural regions involving the gray matter, white matter, and limbic system during acute (12 h) and subacute (3 d and 5 d) phases after hypoxic ischemia (HI), which were validated against histology. Sensory and cognitive parameters were assessed by the open field, novel object recognition, elevated plus maze, and CatWalk tests.ResultsRepeated-measures ANOVA revealed that specific brain structures showed similar trends to the lesion, and the temporal pattern of MK was substantially more varied than DT parameters, particularly in the deep gray matter. The change rate of MK in the acute phase (12 h) was significantly higher than that of DT parameters. We noted a delayed pseudo-normalization for MK. Additionally, MD, AD, and RD showed more pronounced differences between males and females after HI compared to MK, which was confirmed in behavioral tests. HI females exhibited anxiolytic hyperactivity-like baseline behavior, while the memory ability of HI males was affected in the novel object recognition test. CatWalk assessments revealed chronic deficits in limb gait parameters, particularly the left front paw and right hind paw, as well as poorer performance in HI males than HI females.ConclusionsOur results suggested that DK and DT parameters were complementary in the immature brain and provided great value in assessing early tissue microstructural changes and predicting long-term neurobehavioral deficits, highlighting their ability to detect both acute and long-term changes. Thus, the various diffusion coefficient parameters estimated by the DKI model are powerful tools for early HIBD diagnosis and prognosis assessment, thus providing an experimental and theoretical basis for clinical treatment.
引用
收藏
页数:20
相关论文
共 50 条
  • [41] Peritumoral brain regions in gliomas and meningiomas: Investigation with isotropic diffusion-weighted MR imaging and diffusion-tensor MR imaging
    Provenzale, JM
    McGraw, P
    Mhatre, P
    Guo, AC
    Delong, D
    RADIOLOGY, 2004, 232 (02) : 451 - 460
  • [42] Neuroaxonal dystrophy: Imaging, proton MR spectroscopy, and diffusion MR imaging findings
    Mutlu, H.
    Sildiroglu, H. O.
    Sonmez, G.
    Ozturk, E.
    Kizilkaya, E.
    JOURNAL OF NEURORADIOLOGY, 2006, 33 (03) : 207 - 208
  • [43] Current status of body MR imaging: Fast MR imaging and diffusion-weighted imaging
    Koyama T.
    Tamai K.
    Togashi K.
    International Journal of Clinical Oncology, 2006, 11 (4) : 278 - 285
  • [44] MR diffusion tensor imaging: recent advance and new techniques for diffusion tensor visualization
    Masutani, Y
    Aoki, S
    Abe, O
    Hayashi, N
    Otomo, K
    EUROPEAN JOURNAL OF RADIOLOGY, 2003, 46 (01) : 53 - 66
  • [45] Diffusion tensor MR imaging of principal directions: a tensor tomography approach
    Panin, VY
    Zeng, GSL
    Defrise, M
    Gullberg, GT
    PHYSICS IN MEDICINE AND BIOLOGY, 2002, 47 (15): : 2737 - 2757
  • [46] Myocardial fiber length mapping with MR diffusion tensor imaging
    Wu, Y.
    Wu, E. X.
    Wong, K. K.
    Tang, H.
    Tse, H. F.
    Lau, C. P.
    Yang, E. S.
    2005 27TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-7, 2005, : 7004 - 7007
  • [47] Diffusion Tensor MR Imaging in Chronic Spinal Cord Injury
    Ellingson, B. M.
    Ulmer, J. L.
    Kurpad, S. N.
    Schmit, B. D.
    AMERICAN JOURNAL OF NEURORADIOLOGY, 2008, 29 (10) : 1976 - 1982
  • [48] Diffusion tensor MR imaging of the brain and white matter tractography
    Melhem, ER
    Mori, S
    Mukundan, G
    Kraut, MA
    Pomper, MG
    van Zijl, PCM
    AMERICAN JOURNAL OF ROENTGENOLOGY, 2002, 178 (01) : 3 - 16
  • [49] Diffusion tensor MR imaging and fiber tractography: Technical considerations
    Mukherjee, P.
    Chung, S. W.
    Berman, J. I.
    Hess, C. P.
    Henry, R. G.
    AMERICAN JOURNAL OF NEURORADIOLOGY, 2008, 29 (05) : 843 - 852
  • [50] Diffusion-Tensor MR Imaging of the Breast: Hormonal Regulation
    Nissan, Noam
    Furman-Haran, Edna
    Shapiro-Feinberg, Myra
    Grobgeld, Dov
    Degani, Hadassa
    RADIOLOGY, 2014, 271 (03) : 672 - 680