K2CO3-Catalyzed (3+2) Cycloaddition Reaction of N-2,2,2-Trifluoroethylisatin Ketimines with Azodicarboxylates: Access to Spirooxindoles Containing Trifluoromethyl-1,2,4-triazolines

被引：1

作者：

Gu, Jianmin ^{[1
]}

Li, Xiaojing ^{[1
]}

Zhang, Yabo ^{[1
]}

Sun, Zenghui ^{[1
]}

Li, Lin ^{[1
]}

Meng, Jing ^{[1
]}

Xing, Ruijuan ^{[1
]}

Shi, Xiaowei ^{[1
]}

Fu, Yan ^{[1
]}

Wang, Lei ^{[1
,2
]}

Guo, Ran ^{[1
]}

机构：

[1] Hebei Med Univ, Sch Pharm, Dept Med Chem, Shijiazhuang 050017, Peoples R China

[2] Hebei Prov Key Lab Innovat Drug Res & Evaluat, Shijiazhuang 050017, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 04期

基金：

中国国家自然科学基金;

关键词：

1,3-DIPOLAR CYCLOADDITION;

D O I：

10.1021/acs.joc.3c02377

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Potassium carbonate-catalyzed (3 + 2) cycloaddition reaction between N-2,2,2-trifluoroethylisatin ketimines and azodicarboxylates has been developed, constructing a series of novel N-heterocycle infused spirooxindoles in good to excellent yields (up to 98%) under milder conditions. The presence of both biologically active oxindole and trifluoromethyl-1,2,4-triazoline moieties in these novel spirocyclic compounds would provide new lead structures in the discovery of heterocyclic compounds with potential pharmaceutical activities.

引用

页码：2364 / 2374

页数：11

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