High recurrence rate of eczema herpeticum in moderate/severe atopic dermatitis -TREATgermany registry analysis

被引：0

作者：

Traidl, Stephan ^{[1
,2
,18
]}

Heinrich, Luise ^{[3
,4
]}

Siegels, Doreen ^{[3
,4
]}

Roesner, Lennart ^{[1
,2
]}

Haufe, Eva ^{[3
,4
]}

Harder, Inken ^{[5
]}

Abraham, Susanne ^{[6
]}

Ertner, Konstantin ^{[7
]}

Kleinheinz, Andreas ^{[8
]}

Schaekel, Knut ^{[9
]}

Wollenberg, Andreas ^{[10
]}

Effendy, Isaak ^{[11
]}

Quist, Sven ^{[12
]}

Asmussen, Andrea ^{[13
]}

Wildberger, Julia ^{[14
]}

Weisshaar, Elke ^{[15
]}

Wiemers, Franka ^{[16
]}

Bruecher, Jens-Joachim ^{[17
]}

Weidinger, Stephan ^{[5
]}

Schmitt, Jochen ^{[3
,4
]}

Werfel, Thomas ^{[1
,2
]}

TREATgermany Study Grp

机构：

[1] Hannover Med Sch, Dept Dermatol & Allergy, Hannover, Germany

[2] Hannover Med Sch, Cluster Excellence RESIST EXC 2155, Hannover, Germany

[3] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Ctr Evidence Based Healthcare, Dresden, Germany

[4] Tech Univ Dresden, Carl Gustav Carus Fac Med, Dresden, Germany

[5] Univ Hosp Schleswig Holstein, Ctr Inflammatory Skin Dis, Dept Dermatol & Allergy, Campus Kiel, Kiel, Germany

[6] Tech Univ Dresden, Univ Allergy Ctr, Carl Gustav Carus Fac Med, Dept Dermatol, Dresden, Germany

[7] Practice Dr med Konstantin Ertner, Practice Dr, Nurnberg, Germany

[8] Elbe Klinikum Buxtehude, Clin Dermatol, Buxtehude, Germany

[9] Univ Hosp, Dept Dermatol, Heidelberg, Germany

[10] Ludwig Maximilians Univ Munchen, Univ Hosp Augsburg, Dept Dermatol & Allergy, Munich, Germany

[11] Bielefeld Univ, Dept Dermatol, OWL Univ Hosp, Campus Clin Bielefeld, Bielefeld, Germany

[12] Helix Med Ecellence Ctr Mainz, Dermatol Clin, Mainz, Germany

[13] Dermatol Lesum, Practice Dr med Andrea Asmussen, Bremen, Germany

[14] Practice Dr med Julia Wildberger Hautmed, Bad Soden, Germany

[15] Heidelberg Univ, Dept Dermatol, Div Occupat Dermatol, Heidelberg, Germany

[16] Practice Dr med Franca Wiemers, Leipzig, Germany

[17] Hautambulatorium Magdeburg, Practice Dr med Jens Joachim Brucher, Magdeburg, Germany

[18] Hannover Med Sch MHH, Dept Dermatol & Allergy, Carl Neuberg Str 1, D-30625 Hannover, Germany

来源：

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT | 2023年

关键词：

Atopic dermatitis; herpes simplex; registry; OUTCOME MEASURES; DOUBLE-BLIND; EFFICACY; SAFETY; RISK; ADOLESCENTS; ADULTS;

D O I：

10.1111/ddg.15205

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

BackgroundEczema herpeticum (EH) is a disseminated skin infection caused by herpes simplex virus in atopic dermatitis (AD) patients. The frequency of EH and the clinical features of EH patients have not yet been investigated in a larger cohort.MethodsWe sought to investigate the TREATgermany cohort, a multicenter, non-interventional clinical registry of moderately to severely affected AD patients in Germany. Baseline characteristics of patients included between December 2017 and April 2021 were compared between patients without, single, and multiple EH.ResultsOf the 893 patients, 195 (21.8%) had at least one EH. Of the 195 patients with EH, 107 had multiple EH (54.9%), representing 12.0% of the total study population. While there were no differences in demographic characteristics, previous treatment, and disease scores at enrollment (itch, IGA, oSCORAD, EASI), patients with EH had more frequent atopic comorbidities and sensitizations to house dust mite, food, and mold.DiscussionTREATgermany registry data suggest a high prevalence and recurrence rate of EH, while there appears to be no specific clinical phenotype, besides an increase in allergies, to identify EH patients in the daily routine.

引用

页码：1490 / 1498

页数：9

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