Research Status, Synthesis and Clinical Application of Antiepileptic Drugs

被引：3

作者：

Wang, Si-Jie ^{[1
]}

Zhao, Min-Yan ^{[1
]}

Zhao, Peng-Cheng ^{[1
]}

Zhang, Wen ^{[1
]}

Rao, Guo-Wu ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Inst Drug Dev & Chem Biol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2024年 / 31卷 / 04期

关键词：

Brain dysfunction; epilepsy; antiepileptic drugs (AEDs); drugs targets; GABA; glutamate; CONVULSIVE STATUS EPILEPTICUS; TREATMENT-RESISTANT EPILEPSY; JUVENILE MYOCLONIC EPILEPSY; UNCONTROLLED FOCAL SEIZURES; QUALITY-OF-LIFE; REFRACTORY EPILEPSY; DOUBLE-BLIND; ESLICARBAZEPINE ACETATE; ANTICONVULSANT ACTIVITY; ADJUNCTIVE THERAPY;

D O I：

10.2174/0929867330666230117160632

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

According to the 2017 ILAE's official definition, epilepsy is a slow brain disease state characterized by recurrent episodes. Due to information released by ILAE in 2017, it can be divided into four types, including focal epilepsy, generalized epilepsy, combined generalized, and focal epilepsy, and unknown epilepsy. Since 1989, 24 new antiepileptic drugs have been approved to treat different types of epilepsy. Besides, there are a variety of antiepileptic medications under clinical monitoring. These novel antiepileptic drugs have plenty of advantages. Over the past 33 years, there have been many antiepileptic drugs on the mearket, but no one has been found that can completely cure epilepsy. In this paper, the mentioned drugs were classified according to their targets, and the essential information, and clinical studies of each drug were described. The structure-activity relationship of different chemical structures was summarized. This paper provides help for the follow-up research on epilepsy drugs.

引用

页码：410 / 452

页数：43

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