DDX41: exploring the roles of a versatile helicase

被引：2
|
作者：
Winstone, Lacey [1 ]
Jung, Yohan [1 ]
Wu, Yuliang [1 ]
机构：
[1] Univ Saskatchewan, Dept Biochem Microbiol & Immunol, Saskatoon, SK S7N 5E5, Canada
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2024年 / 52卷 / 01期
基金：
加拿大自然科学与工程研究理事会;
关键词：
ACUTE MYELOID-LEUKEMIA; I IFN PRODUCTION; CYCLIC-DI-AMP; FUNCTIONAL-CHARACTERIZATION; R-LOOP; FAMILY; MUTATIONS; VARIANTS; SENSOR; EXPRESSION;
D O I：
10.1042/BST20230725
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
DDX41 is a DEAD-box helicase and is conserved across species. Mutations in DDX41 have been associated with myeloid neoplasms, including myelodysplastic syndrome and acute myeloid leukemia. Though its pathogenesis is not completely known, DDX41 has been shown to have many cellular roles, including in pre-mRNA splicing, innate immune sensing, ribosome biogenesis, translational regulation, and R -loop metabolism. In this review, we will summarize the latest understandings regarding the various roles of DDX41, as well as highlight challenges associated with drug development to target DDX41. Overall, understanding the molecular and cellular mechanisms of DDX41 could help develop novel therapeutic options for DDX41 mutation-related hematologic malignancies.
引用
收藏
页码：395 / 405
页数：11
相关论文
共 50 条
  • [31] Immunostimulatory effect of DDX41 of olive flounder (Paralichthys olivaceus)
    Lazarte, Jassy Mary S.
    Kim, Young Rim
    Lee, Jung Seok
    Im, Se Pyeong
    Kim, Si Won
    Jung, Jae Wook
    Kim, Jaesung
    Lee, Jeong-Ho
    Jung, Tae Sung
    FOOD AND AGRICULTURAL IMMUNOLOGY, 2017, 28 (05) : 876 - 887
  • [32] VEXAS syndrome in a patient with DDX41 germline predisposition syndrome
    Kusne, Yael
    Lasho, Terra
    Finke, Christy
    Patnaik, Mrinal M.
    Badar, Talha
    LEUKEMIA RESEARCH, 2024, 136
  • [33] Variable Clinical Presentation in Individuals with Truncating Variants in DDX41
    Damskey, Ekaterina
    Yan, Jia
    Constantine, Gregory
    Keller, Michael
    Freeman, Alexandra
    Bergerson, Jenna
    Sneller, Michael
    Nath, Avindra
    Similuk, Morgan
    Walkiewicz, Magdalena
    CLINICAL IMMUNOLOGY, 2023, 250 : 139 - 139
  • [34] Pathogenic Mechanisms of DDX41 Mutations in the Development of Myeloid Malignancies
    Kon, Ayana
    Nakagawa, Masahiro Marshall
    Kataoka, Keisuke
    Kakiuchi, Nobuyuki
    Makishima, Hideki
    Nakayama, Manabu
    Koseki, Haruhiko
    Nannya, Yasuhito
    Ogawa, Seishi
    BLOOD, 2023, 142
  • [35] Structural and functional analyses of human DDX41 DEAD domain
    Yan Jiang
    Yanping Zhu
    Weicheng Qiu
    YongJun Liu
    Genhong Cheng
    ZhiJie Liu
    Songying Ouyang
    Protein & Cell, 2017, 8 (01) : 72 - 87
  • [36] DDX41 somatic and germline mutated in acute myeloid leukemia
    Sackfield, B. C.
    Natarajan, A.
    Cartwright, B.
    Bhat, A. H.
    AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2024, 367 : S186 - S187
  • [37] Molecular and functional characterization of tilapia DDX41 in IFN regulation
    Gan, Zhen
    Cheng, Jun
    Hou, Jing
    Xia, Hongli
    Chen, Wenjie
    Xia, Liqun
    Nie, Pin
    Lu, Yishan
    FISH & SHELLFISH IMMUNOLOGY, 2020, 99 : 386 - 391
  • [38] Novel DDX41 variants in Thai patients with myeloid neoplasms
    Polprasert, Chantana
    Takeda, June
    Niparuck, Pimjai
    Rattanathammethee, Thanawat
    Pirunsarn, Arunrat
    Suksusut, Amornchai
    Kobbuaklee, Sirorat
    Wudhikarn, Kitsada
    Lawasut, Panisinee
    Kongkiatkamon, Sunisa
    Chuncharunee, Suporn
    Songserm, Kritanan
    Phowthongkum, Prasit
    Bunworasate, Udomsak
    Nannya, Yasuhito
    Yoshida, Kenichi
    Makishima, Hideki
    Ogawa, Seishi
    Rojnuckarin, Ponlapat
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2020, 111 (02) : 241 - 246
  • [39] Prevalence and significance of DDX41 gene variants in the general population
    Kovilakam, Sruthi Cheloor
    Gu, Muxin
    Dunn, William G.
    Marando, Ludovica
    Nik-Zainal, Serena
    Mohorianu, Irina
    Kar, Siddhartha P.
    Fabre, Margarete A.
    Quiros, Pedro M.
    Vassiliou, George S.
    BLOOD, 2023, 142 (14) : 1185 - 1192
  • [40] Clinical and Pathologic Spectrum of DDX41 Mutated Hematolymphoid Neoplasms
    Goyal, Tanu
    Tu, Zheng Jin
    Cook, James
    LABORATORY INVESTIGATION, 2020, 100 (SUPPL 1) : 1305 - 1306
12345