Characterizing viscoelastic properties of human melanoma tissue using Prony series

被引:8
|
作者
Park, Seungman [1 ,2 ,3 ]
Chien, Anna L. [4 ]
Brown, Isabelle D. [4 ]
Chen, Jingchun [5 ]
机构
[1] Univ Nevada, Dept Mech Engn, Las Vegas, NV 89154 USA
[2] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Inst NanoBio Technol, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Dept Dermatol, Sch Med, Baltimore, MD USA
[5] Univ Nevada, Nevada Inst Personalized Med, Las Vegas, NV USA
基金
美国国家卫生研究院;
关键词
human melanoma tissue; skin cancer; viscoelastic property; stress relaxation; Prony series; shear modulus; relaxation time; viscosity; MECHANICAL-PROPERTIES; MATRIX STIFFNESS; HUMAN SKIN; MICROENVIRONMENT; CELLS; ELASTOGRAPHY; FEASIBILITY; INDENTATION; EXPRESSION;
D O I
10.3389/fbioe.2023.1162880
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Melanoma is the most invasive and deadly skin cancer, which causes most of the deaths from skin cancer. It has been demonstrated that the mechanical properties of tumor tissue are significantly altered. However, data about characterizing the mechanical properties of in vivo melanoma tissue are extremely scarce. In addition, the viscoelastic or viscous properties of melanoma tissue are rarely reported. In this study, we measured and quantitated the viscoelastic properties of human melanoma tissues based on the stress relaxation test, using the indentation-based mechanical analyzer that we developed previously. The melanoma tissues from eight patients of different ages (57-95), genders (male and female patients), races (White and Asian), and sites (nose, arm, shoulder, and chest) were excised and tested. The results showed that the elastic property (i.e., shear modulus) of melanoma tissue was elevated compared to normal tissue, while the viscous property (i.e., relaxation time) was reduced. Moreover, the tissue thickness had a significant impact on the viscoelastic properties, probably due to the amount of the adipose layer. Our findings provide new insights into the role of the viscous and elastic properties of melanoma cell mechanics, which may be implicated in the disease state and progression.
引用
收藏
页数:7
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