Factors and Mechanisms Influencing Conjugation In Vivo in the Gastrointestinal Tract Environment: A Review

被引：10

作者：

Liu, Wei ^{[1
]}

Huang, Yanhu ^{[1
]}

Zhang, Han ^{[1
]}

Liu, Ziyi ^{[1
]}

Huan, Quanmin ^{[1
]}

Xiao, Xia ^{[1
,2
]}

Wang, Zhiqiang ^{[1
,2
,3
]}

机构：

[1] Yangzhou Univ, Coll Vet Med, Yangzhou 225012, Peoples R China

[2] Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225012, Peoples R China

[3] Yangzhou Univ, Inst Comparat Med, Yangzhou 225012, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 06期

基金：

中国国家自然科学基金;

关键词：

horizontal gene transfer; conjugation; plasmid; conjugative frequency; in vivo; intestinal microbiota; ANTIBIOTIC-RESISTANCE BACTERIA; HORIZONTAL GENE-TRANSFER; COLONIZATION RESISTANCE; ESCHERICHIA-COLI; OXIDATIVE STRESS; GUT MICROBIOTA; PLASMID; PROMOTES; PATHOGEN; BIOFILMS;

D O I：

10.3390/ijms24065919

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The emergence and spread of antibiotic resistance genes (ARGs) have imposed a serious threat on global public health. Horizontal gene transfer (HGT) via plasmids is mainly responsible for the spread of ARGs, and conjugation plays an important role in HGT. The conjugation process is very active in vivo and its effect on the spreading of ARGs may be underestimated. In this review, factors affecting conjugation in vivo, especially in the intestinal environment, are summarized. In addition, the potential mechanisms affecting conjugation in vivo are summarized from the perspectives of bacterial colonization and the conjugation process.

引用

页数：16

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