Effects of Supplemented Mediterranean Diets on Plasma-Phospholipid Fatty Acid Profiles and Risk of Cardiovascular Disease after 1 Year of Intervention in the PREDIMED Trial

被引：1

作者：

Razquin, Cristina ^{[1
,2
]}

Ruiz-Canela, Miguel ^{[1
,2
]}

Wernitz, Andreas ^{[3
]}

Toledo, Estefania ^{[1
,2
]}

Corella, Dolores ^{[2
,4
]}

Alonso-Gomez, Angel ^{[2
,5
]}

Fito, Montse ^{[2
,6
]}

Gomez-Gracia, Enrique ^{[2
,7
]}

Estruch, Ramon ^{[2
,8
]}

Fiol, Miquel ^{[2
,9
]}

Lapetra, Jose ^{[2
,10
]}

Serra-Majem, Lluis ^{[2
,11
]}

Ros, Emilio ^{[2
,12
]}

Aros, Fernando ^{[2
,5
]}

Salas-Salvado, Jordi ^{[2
,13
,14
]}

Schulze, Matthias B. ^{[15
,16
]}

Martinez-Gonzalez, Miguel A. ^{[1
,2
,17
]}

机构：

[1] Univ Navarra, IdiSNA, Dept Prevent Med & Publ Hlth, Pamplona, Spain

[2] Inst Salud Carlos III, Ctr Invest Biomed Red CIBER, MP Fisiopatol Obes & Nutr CIBEROBN, Madrid, Spain

[3] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[4] Univ Valencia, Dept Prevent Med, Valencia, Spain

[5] Hosp Univ Alava, Dept Cardiol, Vitoria, Spain

[6] Hosp del Mar Med Res Inst IMIM, Unit Cardiovasc Risk & Nutr, Barcelona, Spain

[7] Univ Malaga, Virgen de la Victoria Hosp, Biomed Res Inst Malaga, Dept Endocrinol, Malaga, Spain

[8] Univ Barcelona, Hosp Clin, Inst Invest Biomed Augist Pi & Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain

[9] Hosp Son Espases, Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca, Spain

[10] Dist Sanitario Atenc Primaria Sevilla, Dept Family Med, Res Unit, Seville, Spain

[11] Univ Las Palmas Gran Canaria, Inst Invest Biomed & Sanitarias, Las Palmas Gran Canaria, Spain

[12] Univ Barcelona, Hosp Clin, Agust Pi & Sunyer Biomed Res Inst IDIBAPS, Dept Endocrinol & Nutr,Lipid Clin, Barcelona, Spain

[13] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain

[14] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus, Spain

[15] German Ctr Diabet Res DZD, Unit Cardiovasc Risk & Nutr, Neuherberg, Germany

[16] Univ Potsdam, Inst Nutr Sci, Potsdam, Germany

[17] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

来源：

CLINICAL CHEMISTRY | 2023年 / 69卷 / 03期

基金：

美国国家卫生研究院;

关键词：

fatty acids; phospholipid fraction; Mediterranean diet; PREDIMED; cardiovascular risk; CORONARY-HEART-DISEASE; OLDER-ADULTS; QUESTIONNAIRE; PREVENTION; BIOMARKER; BLOOD; WOMEN;

D O I：

10.1093/clinchem/hvac221

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background Plasma fatty acids (FAs) have been associated with cardiovascular disease (CVD) risk. Diet and endogenous metabolism influence the FA profile of the plasma phospholipid (PL) fraction. In the PREDIMED trial, we examined 1-year changes in the FA profile of plasma PL according to a nutritional intervention with Mediterranean diets, either supplemented with extra-virgin olive oil (MedDiet + EVOO) or mixed nuts (MedDiet + nuts), in a high cardiovascular risk population. We also analyzed if 1-year changes in PL FAs were associated with subsequent cardiovascular risk. Methods We included 779 participants in our case-cohort study: 185 incident cases and 594 participants in the subcohort (including 31 overlapping cases). The end point was the incidence of CVD. We measured the FAs of plasma PL at baseline and after 1 year of intervention. Results MedDiet + EVOO increased C17:0 and C20:3n9 in linear regression models [beta coefficient(perSD) : 0.215 (95% CI, 0.032-0.399) and 0.271 (0.107-0.434), respectively] and decreased 16:1n7 and C22:4n6 [beta(perSD): -0.239 (95% CI, -0.416 to -0.061) and -0.287 (95% CI, -0.460 to -0.113), respectively] vs the control group. MedDiet + nuts increased C18:3n3 [beta(perSD): 0.382 (95% CI, 0.225 - 0.539)], C18:2n6 [beta(per SD): 0.250 (95% CI, 0.073 - 0.428)], C18:0 [beta(perSD): 0.268 (95% CI, 0.085-0.452)], and C22:0 [beta(per SD): 0.216 (95% CI, 0.031-0.402)]; and decreased the sum of six n6 FAs [beta(per SD): -0.147 (95% CI, -0.268 to -0.027)] vs the control group. The 1-year increase in C18:2n6 was inversely associated with the subsequent CVD risk (HRperSD: 0.64 (95% CI, 0.44-0.92)). Conclusions MedDiet interventions changed n6 FAs and C16:1n7c; other changes were specific for each group: MedDiet + EVOO increased C17:0 and C20:3n9, and MedDiet + Nuts C18:3n3, C18:2n6, C18:0, and C22:0 FAs.

引用

页码：283 / 294

页数：12

共 27 条

[21] Correction to: Different effects of γ-linolenic acid (GLA) supplementation on plasma and red blood cell phospholipid fatty acid composition and calcium oxalate kidney stone risk factors in healthy subjects from two race groups with different risk profiles pose questions about the GLA-arachidonic acid-oxaluria metabolic pathway: pilot study
Allen L. Rodgers
Dalielah Jappie-Mahomed
Paul J. van Jaarsveld
Urolithiasis, 2019, 47 : 215 - 215
[22] Different effects of γ-linolenic acid (GLA) supplementation on plasma and red blood cell phospholipid fatty acid composition and calcium oxalate kidney stone risk factors in healthy subjects from two race groups with different risk profiles pose questions about the GLA-arachidonic acid-oxaluria metabolic pathway: pilot study
Allen L. Rodgers
Dalielah Jappie-Mahomed
Paul J. van Jaarsveld
Urolithiasis, 2018, 46 : 137 - 147
[23] Different effects of γ-linolenic acid (GLA) supplementation on plasma and red blood cell phospholipid fatty acid composition and calcium oxalate kidney stone risk factors in healthy subjects from two race groups with different risk profiles pose questions about the GLA-arachidonic acid-oxaluria metabolic pathway: pilot study
Rodgers, Allen L.
Jappie-Mahomed, Dalielah
van Jaarsveld, Paul J.
UROLITHIASIS, 2018, 46 (02) : 137 - 147
[24] Effects of supplementing n-3 fatty acid enriched eggs and walnuts on cardiovascular disease risk markers in healthy free-living lacto-ovo-vegetarians: a randomized, crossover, free-living intervention study
Burns-Whitmore, Bonny
Haddad, Ella
Sabate, Joan
Rajaram, Sujatha
NUTRITION JOURNAL, 2014, 13
[25] Effects of supplementing n-3 fatty acid enriched eggs and walnuts on cardiovascular disease risk markers in healthy free-living lacto-ovo-vegetarians: a randomized, crossover, free-living intervention study
Bonny Burns-Whitmore
Ella Haddad
Joan Sabaté
Sujatha Rajaram
Nutrition Journal, 13
[26] Different effects of -linolenic acid (GLA) supplementation on plasma and red blood cell phospholipid fatty acid composition and calcium oxalate kidney stone risk factors in healthy subjects from two race groups with different risk profiles pose questions about the GLA-arachidonic acid-oxaluria metabolic pathway: pilot study (vol 46, pg 137, 2018)
Rodgers, Allen L.
Jappie-Mahomed, Dalielah
van Jaarsveld, Paul J.
UROLITHIASIS, 2019, 47 (02) : 215 - 215
[27] Effects of low molecular weight procyanidin rich extract from french maritime pine bark on cardiovascular disease risk factors in stage-1 hypertensive subjects: Randomized, double-blind, crossover, placebo-controlled intervention trial
Valls, Rosa-M
Llaurado, Elisabet
Fernandez-Castillejo, Sara
Puiggros, Francesc
Sola, Rosa
Arola, Lluis
Pedret, Anna
PHYTOMEDICINE, 2016, 23 (12) : 1451 - 1461

← 1 2 3 →