A new potentially hexadentate redox-active schiff base ligand, H2L = 2-((Z)-(2-(2-(2-((Z)-3,5-di-tert-butyl-2hydroxybenzylideneamino)phenylthio)ethylthio)phenylimino)methyl)-4,6-di-tert-butylphenol, reacts with Ni-II(O2CCH3)(2)center dot 4H(2)O and PdCl2 in CH3OH in the presence of air and Et3N affording isolation of yellow and red crystalline solids of composition [Ni(L)] (1) and [Pd-2(L)Cl-2].2CH2Cl2 (2), respectively. When examined by cyclic voltammetry (CV), 1 exhibits three quasireversible responses at E-1/2 = 0.60 V (peak-to peak separation,Delta E-p = 80 mV), 0.96 V (Delta E-p = 80 mV) and 1.16 V (Delta E-p = 160 mV) vs SCE (saturated calomel electrode); while 2 exhibits one quasireversible response at E-1/2 = 1.185 V (peak-to peak separation,Delta E-p = 130 mV). One electron oxidized species showed EPR spectrum correspond to ferromagnetically coupled system, S = 3/2 (S = 1 for NiII and S = 1/2 for phenoxyl radical). Structural analysis revealed that 1 is discrete mononuclear and 2 is discrete dinuclear coordination complex. In complex 1, each Ni-II is in distorted octahedral NiN2O2S2 environment where coordination is satisfied by two nitrogen atoms, two oxygen atoms and two sulfur atoms of the ligand. In complex 2, each Pd is in distorted square planner PdNOSCl environment where coordination is satisfied by one each nitrogen, oxygen and sulfur atoms of the ligand, and a chloride ion. DFT calculations at B3LYP-level of theory adequately describe the electronic structures of 1 and 2, containing a spin-unpaired d(8)Ni(II) ion and spin-paired d(8)Pd(II) ion. Time-dependent-DFT calculations on 1 and 2 shed light on the origin of UV vis NIR spectral absorptions. [Ahmad, Seraj; Kumar, Manoj; Ali, Akram] Univ Allahabad, CMP Coll, Dept Chem, Prayagraj 211002, India; [Javed, Saleem] Jamia Millia Islamia, Dept Chem, New Delhi 110025, Delhi, India; [Singh, Jadveer] Mahamaya Govt Degree Coll, Dept Chem, Dhanupur 221503, India; [Arora, Himanshu] Univ Allahabad, Fac Sci, Dept Chem, Prayagraj 211002, India University of Allahabad; Chaudhary Mahadeo Prasad Degree College; Jamia Millia Islamia; University of Allahabad Ali, A (corresponding author), Univ Allahabad, CMP Coll, Dept Chem, Prayagraj 211002, India.; Arora, H (corresponding author), Univ Allahabad, Fac Sci, Dept Chem, Prayagraj 211002, India. himanshuiitk2004@gmail.com; aliakram96@gmail.com Javed, Saleem/AAC-3394-2021 Javed, Saleem/0000-0003-4623-100X University Grant Com-mission, Government of India (UGC-BSR) [30-461/2019 (BSR)] University Grant Com-mission, Government of India (UGC-BSR) Authors thank Prof. R.N. Mukherjee for using the lab facilities at IIT Kanpur. Authors also thank Dr. Arunava Sengupta for helping in DFT work analysis. This work is supported by the University Grant Com-mission, Government of India (UGC-BSR research start-up grant No. 30-461/2019 (BSR) ) . 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J Alper, P; Betschart, C; Andre, C; Boulay, T; Cheng, D; Deane, J; Faller, M; Feifel, R; Glatthar, R; Han, D; Hemmig, R; Jiang, T; Knoepfel, T; Maginnis, J; Mutnick, D; Pei, W; Ruzzante, G; Syka, P; Zhang, GB; Zhang, Y; Zink, F; Zipfel, G; Hawtin, S; Junt, T; Michellys, PY Alper, Phil; Betschart, Claudia; Andre, Ceïdric; Boulay, Thomas; Cheng, Dai; Deane, Jonathan; Faller, Michael; Feifel, Roland; Glatthar, Ralf; Han, Dong; Hemmig, Rene; Jiang, Tao; Knoepfel, Thomas; Maginnis, Jillian; Mutnick, Daniel; Pei, Wei; Ruzzante, Giulia; Syka, Peter; Zhang, Guobao; Zhang, Yi; Zink, Florence; Zipfel, Geraldine; Hawtin, Stuart; Junt, Tobias; Michellys, Pierre-Yves Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases ACS MEDICINAL CHEMISTRY LETTERS English Article Toll-like receptor 7; toll-like receptor 8; lupus; innate immunity; SAR TOLL-LIKE RECEPTORS; RECOGNITION Toll-like receptor (TLR) 7 and TLR8 are endosomal sensorsof theinnate immune system that are activated by GU-rich single strandedRNA (ssRNA). Multiple genetic and functional lines of evidence linkchronic activation of TLR7/8 to the pathogenesis of systemic autoimmunediseases (sAID) such as Sjo''gren's syndrome (SjS) andsystemic lupus erythematosus (SLE). This makes targeting TLR7/8-inducedinflammation with small-molecule inhibitors an attractive approachfor the treatment of patients suffering from systemic autoimmune diseases.Here, we describe how structure-based optimization of compound 2 resulted in the discovery of 34 (MHV370, (S)-N-(4-((5-(1,6-dimethyl-1H-pyrazolo[3,4-b]pyridin-4-yl)-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)methyl)bicyclo[2.2.2]octan-1-yl)morpholine-3-carboxamide).Its in vivo activity allows for further profilingtoward clinical trials in patients with autoimmune disorders, anda Phase 2 proof of concept study of MHV370 has been initiated, testingits safety and efficacy in patients with Sjo''gren's syndromeand mixed connective tissue disease. [Betschart, Claudia; Andre, Ceïdric; Boulay, Thomas; Faller, Michael; Feifel, Roland; Glatthar, Ralf; Hemmig, Rene; Knoepfel, Thomas; Ruzzante, Giulia; Zink, Florence; Zipfel, Geraldine; Hawtin, Stuart; Junt, Tobias] Novartis Inst Biomed Res, CH-4056 Basel, Switzerland; [Alper, Phil; Cheng, Dai; Deane, Jonathan; Han, Dong; Jiang, Tao; Maginnis, Jillian; Mutnick, Daniel; Pei, Wei; Syka, Peter; Zhang, Guobao; Zhang, Yi; Michellys, Pierre-Yves] Novartis Inst Biomed Res, San Diego, CA 92121 USA Novartis; Novartis Alper, P (corresponding author), Novartis Inst Biomed Res, San Diego, CA 92121 USA. phillip.alper@novartis.com Knoepfel, Thomas/0000-0002-1675-6297 Alper PB, 2020, BIOORG MED CHEM LETT, V30, DOI 10.1016/j.bmcl.2020.127366; Avalos AM, 2010, AUTOIMMUNITY, V43, P76, DOI 10.3109/08916930903374618; Banchereau R, 2016, CELL, V165, P551, DOI 10.1016/j.cell.2016.03.008; Barrat FJ, 2005, J EXP MED, V202, P1131, DOI 10.1084/jem.20050914; Brown GJ, 2022, NATURE, V605, P349, DOI 10.1038/s41586-022-04642-z; Deane JA, 2007, IMMUNITY, V27, P801, DOI 10.1016/j.immuni.2007.09.009; Forsbach A, 2008, J IMMUNOL, V180, P3729, DOI 10.4049/jimmunol.180.6.3729; Ganguly D, 2009, J EXP MED, V206, P1983, DOI 10.1084/jem.20090480; Guiducci C, 2013, J EXP MED, V210, P2903, DOI 10.1084/jem.20131044; Hawtin S, 2023, CELL REP MED, V4, DOI 10.1016/j.xcrm.2023.101036; Herster F, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-13756-4; Junt T, 2015, NAT REV IMMUNOL, V15, P529, DOI 10.1038/nri3875; Kawai T, 2010, NAT IMMUNOL, V11, P373, DOI 10.1038/ni.1863; Knoepfel T, 2020, J MED CHEM, V63, P8276, DOI 10.1021/acs.jmedchem.0c00130; Marshak-Rothstein A, 2007, ANNU REV IMMUNOL, V25, P419, DOI 10.1146/annurev.immunol.22.012703.104514; Rodero MP, 2017, J EXP MED, V214, P1547, DOI 10.1084/jem.20161451; Vlach J, 2021, J PHARMACOL EXP THER, V376, P397, DOI 10.1124/jpet.120.000275 17 1 1 3 3 AMER CHEMICAL SOC WASHINGTON 1155 16TH ST, NW, WASHINGTON, DC 20036 USA 1948-5875 ACS MED CHEM LETT ACS Med. Chem. Lett. JUL 31 2023 14 8 1054 1062 10.1021/acsmedchemlett.3c00136 http://dx.doi.org/10.1021/acsmedchemlett.3c00136 JUL 2023 9 Chemistry, Medicinal Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC) Pharmacology & Pharmacy O5AV1 37583811 2024-05-07 WOS:001040497100001 SCI 2023 2024/05/07 00:00:00 2023_SCI_050710_AD8E3A98A40DDC18_14.txt
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J Ayub, N; Soto, G Ayub, Nicolas; Soto, Gabriela Multiple challenges in the development of commercial crops using CRISPR/Cas technology PLANT SCIENCE English Review CRISPR; Editing; Introgression; Variety; Market The CRISPR/Cas system is a highly efficient and versatile tool for editing plant genomes, with the potential to accelerate breeding programs and improve the sustainability of food production. Nevertheless, technical limitations delay the rapid spread of the CRISPR/Cas system benefits in agriculture. The natural features of plant species, including reproductive behavior, ploidy levels, genetic diversity, and generation times, can significantly impact the introgression of edited traits into elite germplasms. The production and selection of edited events require the same level of effort as those of their transgenic equivalents. Additionally, edited alleles tend to be recessive or not fully dominant, which differs from dominant transgenic events. To accelerate the introgression of edited events into conventional and transgenic varieties, we suggest utilizing edits on single-copy genes that induce dominant mutations. In the absence of new, simple traits that provide exceptional economic benefits for large companies, like herbicide tolerance in transgenic crops, we propose the emergence of particular public grants for edited variety productions, especially when the introgression shows a high level of technical feasibility. In the context of climate change, these public actions must be taken quickly to alleviate significant reductions in crop production. [Ayub, Nicolas; Soto, Gabriela] INTA, CONICET, Inst Agrobiotecnol & Biol Mol IABIMO, Buenos Aires, Argentina; [Ayub, Nicolas; Soto, Gabriela] INTA, Inst Genet IGEAF, Acronym, Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Instituto Nacional de Tecnologia Agropecuaria (INTA); Instituto Nacional de Tecnologia Agropecuaria (INTA) Soto, G (corresponding author), INTA, CONICET, Inst Agrobiotecnol & Biol Mol IABIMO, Buenos Aires, Argentina. soto.gabrielacinthia@inta.gob.ar Ayub, Nicolas/0000-0001-5012-240X Abdelrahman M, 2021, FRONT PLANT SCI, V12, DOI 10.3389/fpls.2021.721203; Apse MP, 1999, SCIENCE, V285, P1256, DOI 10.1126/science.285.5431.1256; Arora NK., 2019, Environmental Sustainability, V2, P95, DOI [10.1007/s42398-019-00078-w, DOI 10.1007/S42398-019-00078-W]; Buchholzer M, 2023, NEW PHYTOL, V237, P12, DOI 10.1111/nph.18333; Frare R, 2018, J MOL EVOL, V86, P554, DOI 10.1007/s00239-018-9867-3; Kemp L, 2022, P NATL ACAD SCI USA, V119, DOI 10.1073/pnas.2108146119; Lewi DM, 2020, FRONT BIOENG BIOTECH, V8, DOI 10.3389/fbioe.2020.00301; Mallapaty S, 2022, NATURE, V602, P559, DOI 10.1038/d41586-022-00395-x; Pabuayon I.C.M., 2021, STRESS BIOL, V1, P14; Panchy N, 2016, PLANT PHYSIOL, V171, P2294, DOI 10.1104/pp.16.00523; Di Giorgio JAP, 2016, PLANT CELL, V28, P1053, DOI 10.1105/tpc.15.00776; Pixley KV, 2022, NAT GENET, V54, P364, DOI 10.1038/s41588-022-01046-7; Sánchez-Gómez C, 2023, METHODS MOL BIOL, P459, DOI 10.1007/978-1-0716-2561-3_24; Shan QW, 2013, NAT BIOTECHNOL, V31, P686, DOI 10.1038/nbt.2650; Stritzler M, 2018, J BIOTECHNOL, V276, P42, DOI 10.1016/j.jbiotec.2018.04.013; Tyczewska A, 2023, TRENDS BIOTECHNOL, V41, P331, DOI 10.1016/j.tibtech.2022.12.013; Utomo JC, 2021, FRONT PLANT SCI, V12, DOI 10.3389/fpls.2021.719148; Waltz E, 2022, NAT BIOTECHNOL, V40, P9, DOI 10.1038/d41587-021-00026-2; Zambryski P, 2013, INT J DEV BIOL, V57, P449, DOI 10.1387/ijdb.130190pz; Zhang R, 2019, NAT PLANTS, V5, P480, DOI 10.1038/s41477-019-0405-0 20 0 0 4 5 ELSEVIER IRELAND LTD CLARE ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND 0168-9452 1873-2259 PLANT SCI Plant Sci. OCT 2023 335 111809 10.1016/j.plantsci.2023.111809 http://dx.doi.org/10.1016/j.plantsci.2023.111809 JUL 2023 3 Biochemistry & Molecular Biology; Plant Sciences Science Citation Index Expanded (SCI-EXPANDED) Biochemistry & Molecular Biology; Plant Sciences P5DE6 37482301 2024-05-07 WOS:001050867100001 SCI 2023 2024/05/07 00:00:00 2023_SCI_050710_AD8E3A98A40DDC18_14.txt
J Bhat, P; Kumaran, SS; Goyal, V; Srivastava, AK; Behari, M Bhat, Priyanka; Kumaran, S. Senthil; Goyal, Vinay; Srivastava, Achal K.; Behari, Madhuri Effect of rTMS at SMA on task-based connectivity in PD BEHAVIOURAL BRAIN RESEARCH English Article Parkinson's Disease (PD); Repetitive Transcranial Magnetic Stimulation (rTMS); Supplementary Motor Area (SMA); Multivariate Pattern Analysis (MVPA) SUPPLEMENTARY MOTOR AREA; FUNCTIONAL CONNECTIVITY; PARKINSONS-DISEASE; STIMULATION Background: Transcranial magnetic stimulation (TMS) can aid in alleviating clinical symptoms in Parkinson's disease (PD). To better understand the neural mechanism of the intervention, neuroimaging modalities have been used to assess the effects of rTMS.Objective: To study the changes in cortical connectivity and motor performance with rTMS at supplementary motor area (SMA) in PD using clinical assessment tools and task-based functional MRI. Methodology: 3000 pulses at 5 Hz TMS were delivered at the left SMA once a week for a total of 8 consecutive weeks in 4 sham sessions (week 1-4) and 4 real sessions (week 5 to week 8) in 16 subjects with PD. The outcomes were assessed with UPDRS, PDQ 39 and task-based fMRI at baseline, after sham sessions at week 4, and after real sessions at week 8. Visuo-spatial functional MRI task along with T1 weighted scans (at 3 Tesla) were used to evaluate the effects of rTMS intervention. Multivariate pattern analysis (MVPA) was used to analyse task-based fMRI using Conn toolbox.Results: Improvements (p < 0.05) were observed in UPDRS II, III, Mobility and ADL of PDQ39 after real sessions of rTMS. MVPA of task-based connectivity revealed clusters of activation in right hemispheric precentral area, superior frontal gyrus, middle frontal gyrus, thalamus and cerebellum (cluster threshold pFDR=0.001).Conclusions: Weekly rTMS sessions at SMA incurred clinical motor benefits as revealed by an improvement in clinical scales and dexterity performance. These benefits could be attributed to changes in connectivity remote brain regions in the motor network. [Bhat, Priyanka; Goyal, Vinay; Srivastava, Achal K.; Behari, Madhuri] All India Inst Med Sci AIIMS, Dept Neurol, New Delhi 110029, India; [Kumaran, S. Senthil] All India Inst Med Sci AIIMS, Dept NMR, New Delhi 110029, India; [Goyal, Vinay] The Medicity, Dept Neurol, Medanta, Gurgaon, India; [Behari, Madhuri] Fortis Flt Lt RajanDhall Hosp, Dept Neurol, New Delhi 110070, India All India Institute of Medical Sciences (AIIMS) New Delhi; All India Institute of Medical Sciences (AIIMS) New Delhi Kumaran, SS (corresponding author), All India Inst Med Sci AIIMS, Dept NMR, New Delhi 110029, India. senthil@aiims.edu Srivastava, Achal Kumar/O-4099-2017 Srivastava, Achal Kumar/0000-0002-4590-7947; Kumaran, S Senthil/0000-0002-4275-0139 SERB [SERB/F/4097/2014-15] SERB(Department of Science & Technology (India)Science Engineering Research Board (SERB), India) Funding from SERB, Govt. India (SERB/F/4097/2014-15) is acknowledged. The infrastructural support was provided by the institute. 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J Bilu, YF; Gun, S; Naik, SL Bilu, Yuri F.; Gun, Sanoli; Naik, Sunil L. On a non-Archimedean analogue of a question of Atkin and Serre MATHEMATISCHE ANNALEN English Article; Early Access FOURIER COEFFICIENTS; DIVISORS In this article, we investigate a non-Archimedean analogue of a question of Atkin and Serre. More precisely, we derive lower bounds for the largest prime factor of non-zero Fourier coefficients of non-CM normalized cuspidal Hecke eigenforms of even weight k >= 2, level N with integer Fourier coefficients. In particular, we show that for such a form f and for any real number epsilon > 0, the largest prime factor of the p-th Fourier coefficient a(f) (p) of f, denoted by P(a(f)(p)), satisfies P(a(f) (p)) > (log p)(1/8) (log log p)(3/8-epsilon) for almost all primes p. This improves on earlier bounds. We also investigate a number field analogue of a recent result of Bennett, Gherga, Patel and Siksek about the largest prime factor of a(f) (p(m)) for m >= 2. [Bilu, Yuri F.] Univ Bordeaux, Inst Math Bordeaux UMR 5251, F-33405 Talence, France; [Bilu, Yuri F.] CNRS, F-33405 Talence, France; [Gun, Sanoli; Naik, Sunil L.] A CI Homi Bhabha Natl Inst, Inst Math Sci, CIT Campus, Chennai 600113, India Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Mathematical Sciences (INSMI); Centre National de la Recherche Scientifique (CNRS); Institute of Mathematical Sciences (IMSc) India Gun, S (corresponding author), A CI Homi Bhabha Natl Inst, Inst Math Sci, CIT Campus, Chennai 600113, India. yuri@math.u-bordeaux.fr; sanoli@imsc.res.in; sunilnaik@imsc.res.in Naik, Sunil L/0000-0003-1369-2627 SPARC project [445]; Indo French program in Mathematics (IFPM); DAE number theory plan project SPARC project; Indo French program in Mathematics (IFPM); DAE number theory plan project The authors would like to thank Ram Murty, Purusottam Rath and the referee for valuable suggestions. The authors would also like to thank SPARC project 445 for partial financial support and Indo French program in Mathematics (IFPM). The second and the third author would also like to acknowledge the support of DAE number theory plan project. Barnet-Lamb T, 2011, PUBL RES I MATH SCI, V47, P29, DOI 10.2977/PRIMS/31; Bennett MA, 2022, MATH ANN, V382, P203, DOI 10.1007/s00208-021-02241-3; Bilu Y, 2022, ACTA ARITH, V206, P223, DOI 10.4064/aa211116-13-11; Bugeaud Y, 2000, B LOND MATH SOC, V32, P673, DOI 10.1112/S0024609300007487; Clozel L, 2008, PUBL MATH-PARIS, P1, DOI 10.1007/s10240-008-0016-1; Crandall R, 1997, MATH COMPUT, V66, P433, DOI 10.1090/S0025-5718-97-00791-6; Dobrowolski E., 1979, Acta Arith., V34, P391, DOI DOI 10.4064/AA-34-4-391-401; Garaev MZ, 2007, ARCH MATH, V89, P411, DOI 10.1007/s00013-007-2246-8; Gun S, 2014, NEW YORK J MATH, V20, P229; Halberstam H., 1974, London Math. Soc. Monogr., V4; Harris M, 2010, ANN MATH, V171, P779, DOI 10.4007/annals.2010.171.779; Hong HJ, 2022, BOL SOC MAT MEX, V28, DOI 10.1007/s40590-022-00453-4; Kowalski E, 2007, REV MAT IBEROAM, V23, P281; Lagarias J. C., 1977, Algebraic number fields: L-functions and Galois properties, P409; Luca F, 2006, P INDIAN AS-MATH SCI, V116, P1, DOI 10.1007/BF02829735; Murty MR, 2019, J NUMBER THEORY, V201, P1, DOI 10.1016/j.jnt.2019.02.016; Murty MR, 2007, INT J NUMBER THEORY, V3, P455, DOI 10.1142/S1793042107001036; MURTY MR, 1984, DUKE MATH J, V51, P57, DOI 10.1215/S0012-7094-84-05104-4; MURTY MR, 1988, AM J MATH, V110, P253, DOI 10.2307/2374502; Ribet K.A., 1977, LECT NOTES MATH, V601, P17; SCHINZEL A, 1974, J REINE ANGEW MATH, V268, P27; Serre J.-P., 1976, Enseign. Math., V22, P227; Serre J-P., 1981, Publ. Math. IHES, V54, P123; Shimura G., 1994, Introduction to the arithmetic theory of automorphic functions, V11; Stewart CL, 2013, ACTA MATH-DJURSHOLM, V211, P291, DOI 10.1007/s11511-013-0105-y; Thorner J, 2019, ALGEBR NUMBER THEORY, V13, P1039, DOI 10.2140/ant.2019.13.1039; Voutier P, 1996, ACTA ARITH, V74, P81 27 1 1 0 0 SPRINGER HEIDELBERG HEIDELBERG TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY 0025-5831 1432-1807 MATH ANN Math. Ann. 2023 JUL 31 2023 10.1007/s00208-023-02686-8 http://dx.doi.org/10.1007/s00208-023-02686-8 JUL 2023 28 Mathematics Science Citation Index Expanded (SCI-EXPANDED) Mathematics O0NO7 Green Submitted 2024-05-07 WOS:001040877100001 SCI 2023 2024/05/07 00:00:00 2023_SCI_050710_AD8E3A98A40DDC18_14.txt
J Calhoun, J; Kline-Tilford, A; Verger, J Calhoun, Jackie; Kline-Tilford, Andrea; Verger, Judy Evolution of Pediatric Critical Care Nursing CRITICAL CARE NURSING CLINICS OF NORTH AMERICA English Article PICU; Nursing; Pediatrics; Critical care; History FAMILY-CENTERED CARE; SIMULATION; UNIT; INFECTIONS; GUIDELINES; MANAGEMENT; CHILDREN; SUPPORT; SCORE [Calhoun, Jackie] Univ Pittsburgh, UPMC Childrens Hosp Pittsburgh, Sch Nursing, 3500 Victoria St,440 Victoria Bldg, Pittsburgh, PA 15261 USA; [Kline-Tilford, Andrea] Univ Michigan Hlth Syst, Ann Arbor, MI USA; [Verger, Judy] Univ Iowa, Coll Nursing, Iowa City, IA USA; [Kline-Tilford, Andrea] 656 Thayer Blvd, Northville, MI 48167 USA Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Michigan System; University of Michigan; University of Iowa Kline-Tilford, A (corresponding author), Univ Michigan Hlth Syst, Ann Arbor, MI USA.; Kline-Tilford, A (corresponding author), 656 Thayer Blvd, Northville, MI 48167 USA. aklinetilford@gmail.com Calhoun, Jackie/0000-0003-0826-4740 Ahmed SS, 2012, PEDIATR CRIT CARE ME, V13, pE69, DOI 10.1097/PCC.0b013e31820ac2e1; Akre M, 2010, PEDIATRICS, V125, pE763, DOI 10.1542/peds.2009-0338; Algarni AS, 2022, WORLD J PEDIATR, V18, P83, DOI 10.1007/s12519-021-00499-w; American Association of Critical Care Nurses, 2023, HIST AACN; American Association of Critical Care Nurses, 2023, BEAC AW; Bankhead S, 2014, NURS CLIN N AM, V49, P321, DOI 10.1016/j.cnur.2014.05.006; Bardella IJ, 1999, AM FAM PHYSICIAN, V60, P1743; Barr P, 2022, AUST CRIT CARE, V35, P174, DOI 10.1016/j.aucc.2021.03.007; BARTLETT RH, 1976, T AM SOC ART INT ORG, V22, P80; Blake N, 2022, AACN ADV CRIT CARE, V33, P99, DOI 10.4037/aacnacc2022286; Butler A, 2014, J CLIN NURS, V23, P2086, DOI 10.1111/jocn.12498; Cooper VB, 2013, CRIT CARE NURSE, V33, P21, DOI 10.4037/ccn2013204; CPCCRN, About us; Cummins KA, 2019, NURS CLIN N AM, V54, P127, DOI 10.1016/j.cnur.2018.10.005; Curley MAQ, 2003, NURS RES, V52, P22, DOI 10.1097/00006199-200301000-00004; Curley MAQ, 2018, TRIALS, V19, DOI 10.1186/s13063-018-3075-8; Davidson JE, 2017, CRIT CARE MED, V45, P103, DOI 10.1097/CCM.0000000000002169; Eppich WJ, 2006, CURR OPIN PEDIATR, V18, P266, DOI 10.1097/01.mop.0000193309.22462.c9; Epstein D, 2005, PEDIATR RES, V58, P987, DOI 10.1203/01.PDR.0000182822.16263.3D; Foglia DC, 2011, CRIT CARE NURS CLIN, V23, P239, DOI 10.1016/j.ccell.2011.02.003; Green J., 2021, PEDIATR NURS, V47, P163; GRENVIK A, 1985, CRIT CARE MED, V13, P1001, DOI 10.1097/00003246-198512000-00001; Hartman ME, 2020, PEDIATR NEUROL, V108, P47, DOI 10.1016/j.pediatrneurol.2020.02.003; Hennon TR, 2020, PROG PEDIATR CARDIOL, V57, DOI 10.1016/j.ppedcard.2020.101232; Kissel KA, 2023, CRIT CARE NURSE, V43, P55, DOI 10.4037/ccn2023196; Lambert V, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-014497; Levin D.L., 2011, Pediatric Critical Care, V4th; Levin DL, 2013, J PEDIATR INTENSIVE, V2, P147, DOI 10.3233/PIC-13068; Lin YQ, 2015, ADV MED EDUC PRACT, V6, P239, DOI 10.2147/AMEP.S64178; Lincoln PA, 2020, PEDIATR CRIT CARE ME, V21, P1064, DOI 10.1097/PCC.0000000000002505; MaGowan N., 2020, PEDIATR NURS, V46, P273; Manning JC, 2018, PEDIATR CRIT CARE ME, V19, P298, DOI 10.1097/PCC.0000000000001476; Matsuishi Y, 2021, INTENS CRIT CARE NUR, V67, DOI 10.1016/j.iccn.2021.103082; Munro CL, 2022, AM J CRIT CARE, V31, P4, DOI 10.4037/ajcc2022603; National Academy of Medicine, NAT PLAN HLTH WORKF; Pediatric Nursing Certification Board, 2023, US; Pediatric Nursing Certification Board, 2023, CPNP AC ROL; Skaletzky SM, 2012, CLIN PEDIATR, V51, P431, DOI 10.1177/0009922811430342; Snyder MD, 2020, CRIT CARE NURSE, V40, pE12, DOI 10.4037/ccn2020438; Society of Critical Care Medicine, AWARDS; Society of Critical Care Medicine, SURV SEPS CAMP SURV; Society of Critical Care Medicine, 2023, COMMUNICATION; Talbird SE, 2022, PEDIATRICS, V150, DOI 10.1542/peds.2021-056013; Tanne JH, 2022, BMJ-BRIT MED J, V379, DOI 10.1136/bmj.o2681; Thomas TA, 2021, AM J CRIT CARE, V30, pE80, DOI 10.4037/ajcc2021999; Ullman AJ, 2014, NURS EDUC TODAY, V34, P202, DOI 10.1016/j.nedt.2013.09.002; US Department of Health and Human Services, Addressing Health Worker Burnout. 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J Chambers, A; Mackay, D; Farnsworth, K; Morrison, AE; Witteman, HO; Mbbs, PS; Halperin, IJ; Bajaj, HS; Barnes, T; Gilbert, J; Honshorst, K; Kim, J; Lewis, J; MacDonald, B; Mackay, D; Mansell, K; Senior, P; Rabi, D; Sherifali, D Chambers, Alanna; Mackay, Dylan; Farnsworth, Kate; Morrison, Amy E.; Witteman, Holly O.; Mbbs, Peter Senior; Halperin, Ilana J.; Bajaj, Harpreet S.; Barnes, Tracy; Gilbert, Jeremy; Honshorst, Kristin; Kim, James; Lewis, Joanne; MacDonald, Barbara; Mackay, Dylan; Mansell, Kerry; Senior, Peter; Rabi, Doreen; Sherifali, Diana Diabet Canada Clinical Practice; Diabet Canada Clinical Practice Do-It-Yourself Automated Insulin Delivery: A Health-care Practitioner User's Guide CANADIAN JOURNAL OF DIABETES English Article [Barnes, Tracy] Clin Practice Guidelines Diabet Canada, Toronto, ON, Canada Barnes, T (corresponding author), Clin Practice Guidelines Diabet Canada, Toronto, ON, Canada. tracy.barnes@diabetes.ca Senior, Peter/O-4934-2019; Sherifali, Diana/AGZ-4409-2022 Senior, Peter/0000-0003-1033-8673; Sherifali, Diana/0000-0002-4423-3848 Android APS, US; Braune K, 2022, J MED INTERNET RES, V24, DOI 10.2196/37120; Braune K, 2022, LANCET DIABETES ENDO, V10, P58, DOI 10.1016/S2213-8587(21)00267-9; Cemeroglu AP, 2013, ENDOCR PRACT, V19, P805, DOI 10.4158/EP13099.OR; Chan AJ, 2021, CAN J DIABETES, V45, P269, DOI 10.1016/j.jcjd.2020.08.103; Farnsworth K, 2022, ADV TECHNOLOGIES TRE, DOI [10.1089/dia.2022.2525.abstracts, DOI 10.1089/DIA.2022.2525.ABSTRACTS]; github, LOOPDOCS; Lal RA, 2019, ENDOCR REV, V40, P1521, DOI 10.1210/er.2018-00174; Lawton J, 2020, DIABETIC MED, V37, P1030, DOI 10.1111/dme.14252; Messer LH, 2019, DIABETES TECHNOL THE, V21, P462, DOI 10.1089/dia.2019.0105; Mewes D, 2023, J DIABETES SCI TECHN, V17, P1304, DOI 10.1177/19322968221080199; OpenAPS, US; Phillip M, 2023, ENDOCR REV, V44, P254, DOI 10.1210/endrev/bnac022; Riddell MC, 2017, LANCET DIABETES ENDO, V5, P377, DOI 10.1016/S2213-8587(17)30014-1; Suttiratana SC, 2022, DIABETES TECHNOL THE, V24, P416, DOI 10.1089/dia.2021.0485; Van Os M, 2022, ATTD; Walsh J, 2022, J DIABETES SCI TECHN, DOI DOI 10.1177/19322968221087261 17 1 1 0 0 ELSEVIER AMSTERDAM RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS 1499-2671 2352-3840 CAN J DIABETES Can. J. Diabetes JUL 2023 47 5 10.1016/j.jcjd.2023.06.001 http://dx.doi.org/10.1016/j.jcjd.2023.06.001 JUL 2023 17 Endocrinology & Metabolism Science Citation Index Expanded (SCI-EXPANDED) Endocrinology & Metabolism P5NG9 37532366 2024-05-07 WOS:001051137100001 SCI 2023 2024/05/07 00:00:00 2023_SCI_050710_AD8E3A98A40DDC18_14.txt
J Chen, ZY; Shen, QQ; Xiong, JZ; Jiang, JM; Ju, ZC; Zhang, XG Chen, Ziyu; Shen, Qianqian; Xiong, Jianzhen; Jiang, Jiangmin; Ju, Zhicheng; Zhang, Xiaogang Advanced Electrode Materials for Potassium-Ion Hybrid Capacitors BATTERIES & SUPERCAPS English Review potassium-ion hybrid capacitors; electrode materials; energy storage mechanism; energy density; development prospect GRAPHENE OXIDE; K-ION; SUB-MICROSPHERES; PERFORMANCE; STORAGE; ANODE; LITHIUM; BATTERIES; NITROGEN; PROGRESS Potassium-ion hybrid capacitors (PIHCs) overcome the limitations of potassium-ion batteries (PIBs) and supercapacitors (SCs) and integrate the advantages of both, including high energy density, high power density, low cost, long cycle life, and stable electrochemical performance. However, the development of PIHCs is hindered by thermodynamic instability and kinetic hysteresis. Additionally, the dynamic mismatch between anode and cathode materials poses an urgent challenge. To this end, many research works related to material development have been dedicated to overcoming the drawbacks. In this review, the energy storage mechanism of PIHCs is briefly introduced. Moreover, the research progress and achievements of anode and cathode materials in recent years are reviewed, including carbon-based materials, MXenes, transition metal materials, Prussian blue and its analogues. Finally, the challenges and prospects of PIHCs are proposed, together with guiding significant research directions in the future. [Chen, Ziyu; Shen, Qianqian; Xiong, Jianzhen; Jiang, Jiangmin; Ju, Zhicheng] China Univ Min & Technol, Equipments Sch Mat Sci & Phys, Jiangsu Prov Engn Lab High Efficient Energy Storag, Xuzhou 221116, Peoples R China; [Jiang, Jiangmin; Zhang, Xiaogang] Nanjing Univ Aeronaut & Astronaut, Jiangsu Key Lab Electrochem Energy Storage Technol, Nanjing 210016, Peoples R China China University of Mining & Technology; Nanjing University of Aeronautics & Astronautics Jiang, JM; Ju, ZC (corresponding author), China Univ Min & Technol, Equipments Sch Mat Sci & Phys, Jiangsu Prov Engn Lab High Efficient Energy Storag, Xuzhou 221116, Peoples R China.; Jiang, JM; Zhang, XG (corresponding author), Nanjing Univ Aeronaut & Astronaut, Jiangsu Key Lab Electrochem Energy Storage Technol, Nanjing 210016, Peoples R China. jiangmin326@163.com; juzc@cumt.edu.cn; azhangxg@nuaa.edu.cn , Zhicheng/O-2116-2016 , Zhicheng/0000-0002-6316-282X; Jiang, Jiangmin/0000-0003-4876-1135; Zhang, Xiaogang/0000-0003-4464-672X National Natural Science Foundation of China [U1802256, 22209204, 22279162, 21975283]; Natural Science Foundation of Jiangsu Province [BK20221140]; China Postdoctoral Science Foundation [2022M713364]; Fundamental Research Funds for the Central Universities [2022QN1088]; Material Science and Engineering Discipline Guidance Fund of China University of Mining and Technology [CUMTMS202208] National Natural Science Foundation of China(National Natural Science Foundation of China (NSFC)); Natural Science Foundation of Jiangsu Province(Natural Science Foundation of Jiangsu Province); China Postdoctoral Science Foundation(China Postdoctoral Science Foundation); Fundamental Research Funds for the Central Universities(Fundamental Research Funds for the Central Universities); Material Science and Engineering Discipline Guidance Fund of China University of Mining and Technology Acknowledgments This work was supported by the National Natural Science Foundation of China (U1802256, 22209204, 22279162, 21975283), the Natural Science Foundation of Jiangsu Province (BK20221140), the China Postdoctoral Science Foundation (2022M713364), the Fundamental Research Funds for the Central Universities (2022QN1088), the Material Science and Engineering Discipline Guidance Fund of China University of Mining and Technology (CUMTMS202208). 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J da Silva, S; Pérez-Gregorio, R; Mateus, N; Freitas, V; Dias, R da Silva, Sara; Perez-Gregorio, Rosa; Mateus, Nuno; Freitas, Victor; Dias, Ricardo Evidence of increased gluten-induced perturbations in the nucleophilic tone and detoxifying defences of intestinal epithelial cells impaired by gastric disfunction FOOD RESEARCH INTERNATIONAL English Article Celiac disease; Oxidative stress; Gluten peptides; Gluten digestion CELIAC-DISEASE; QUANTITATIVE-DETERMINATION; CACO-2; WHEAT; GLUTATHIONE; PEPTIDES; HT-29; ASSAY; LINE It has been increasingly demonstrated over the past few years that some proteolytically resistant gluten peptides may directly affect intestinal cell structure and functions by modulating pro-inflammatory gene expression and oxidative stress. The relationship between oxidative cell damage and Celiac Disease (CD) is supported by several studies on human intestinal epithelial cell lines, such as the Caco-2 cell model, already shown to be particularly sensitive to the pro-oxidative and pro-apoptotic properties of gluten protein digests. Through providing valuable evidence concerning some of the pathophysiological mechanisms that may be at play in gluten-related disorders, most of these in vitro studies have been employing simplified digestion schemes and intestinal cell systems that do not fully resemble mature enterocytes in terms of their characteristic tight junctions, microvilli and membrane transporters. Herein the peptide profile and pro-oxidative effect of two different gastrointestinal gliadin digestions was thoroughly characterized and comprehensively compared: one following the complete INFOGEST workflow and a second one by-passing gastric processing, to assess the dependence of gliadin-triggered downstream cell effects on pepsin activity. In both matrices, gluten-derived immunogenic peptide sequences were identified by non-targeted LC-MS/MS. Altogether, this study provides first-hand data concerning the still unexplored peptide composition, gastric-dependence and immunogenicity of physiologically representative gliadin protein digests as well as foundational clues stressing the need for more complex and integrated in vitro cell systems when modelling and exploiting gluten-induced perturbations in the nucleophilic tone and inflammatory status of intestinal epithelial cells. [da Silva, Sara; Perez-Gregorio, Rosa; Mateus, Nuno; Freitas, Victor; Dias, Ricardo] Univ Porto, Dept Chem & Biochem, LAQV REQUIMTE, Fac Sci, Porto, Portugal; [Perez-Gregorio, Rosa] Univ Vigo, Dept Analyt & Food Chem, Nutr & Bromatol Area, Fac Sci, Orense, Spain Universidade do Porto; Universidade de Vigo Dias, R (corresponding author), Univ Porto, Dept Chem & Biochem, LAQV REQUIMTE, Fac Sci, Porto, Portugal. ricardo.dias@fc.up.pt Perez Gregorio, Maria Rosa/A-3373-2014; Mateus, Nuno/F-3019-2013 Perez Gregorio, Maria Rosa/0000-0003-3030-5799; Correia Dias, Ricardo Jorge/0000-0003-2664-8473; Mateus, Nuno/0000-0002-9318-9732 FCT/MCTES through national funds [UIDB/50006/2020] FCT/MCTES through national funds(Fundacao para a Ciencia e a Tecnologia (FCT)) Funding This work was financially supported through the project UIDB/50006/2020, funded by FCT/MCTES through national funds. 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J Dong, YT; Wang, WH; Su, GL; Liu, L Dong, Yutong; Wang, Wenhao; Su, Guanlong; Liu, Lei Active control strategy for low frequency vibration of space flexible cables based on improved sliding mode controller JOURNAL OF LOW FREQUENCY NOISE VIBRATION AND ACTIVE CONTROL English Article flexible cable low frequency vibration; sliding mode control; dual power reaching law; radial basis function neural network; extended state observer; particle swarm optimization MANIPULATORS; ROBOT Effective vibration control of flexible cables is increasingly demanded for space flexible structure. For the low frequency dynamics of flexible cables, a novel vibration control strategy based on sliding mode control is proposed in this paper. First, the complex dynamical behavior of flexible cables is modeled using D'Alembert's principle. Second, an improved dual power reaching law is put forward to better address the chattering problem of the sliding mode controller. Then, an extended state observer (ESO) with the radial basis function (RBF) neural network is designed to compensate for internal uncertainties and external disturbances as well as further improve the control accuracy. Lyapunov function is employed to analyze the stability of the system. Finally, considering the large number of parameters of the proposed controller, an improved particle swarm optimization (PSO) algorithm is designed to automatically adjust these parameters. The effectiveness of the proposed method is demonstrated by simulation results. [Dong, Yutong; Wang, Wenhao; Liu, Lei] Northwestern Polytech Univ, Sch Astronaut, Xian, Peoples R China; [Su, Guanlong] Xian Inst Space Radio Technol, Antenna Stn, Xian, Peoples R China; [Liu, Lei] Northwestern Polytech Univ, Sch Astronaut, 127 West Youyi Rd, Xian, Shaanxi, Peoples R China Northwestern Polytechnical University; Northwestern Polytechnical University Liu, L (corresponding author), Northwestern Polytech Univ, Sch Astronaut, 127 West Youyi Rd, Xian, Shaanxi, Peoples R China. leiliu@nwpu.edu.cn Dong, Yutong/0000-0003-4516-8483 National Natural Science Foundation of China [52075446, 51675430] National Natural Science Foundation of China(National Natural Science Foundation of China (NSFC)) The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the authors are grateful for the financial support of the National Natural Science Foundation of China (52075446,51675430). 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J Duan, XP; Zhao, WB; Ma, GL Duan, Xiang-Pan; Zhao, Wenbin; Ma, Guo-Liang Hadronization effects on transverse momentum dependent jet fragmentation function in small systems EUROPEAN PHYSICAL JOURNAL PLUS English Article QUARK-GLUON PLASMA; ENERGY-LOSS; PARTON; MATTER; PERSPECTIVE; COLLISIONS The transverse momentum jT-dependent jet fragmentation functions have been investigated in proton+proton (p + p) and proton+lead (p + Pb) collisions at vsNN = 5.02 TeV with a multiphase transport model containing both a simple quark coalescence mechanism and a new hybrid hadronization mechanism with coalescence and fragmentation processes. Hadronized by the new hadronization mechanism, the AMPT model achieves a quantitative description of the jT-dependent jet fragmentation functions measured by ALICE. Besides, no obvious jet-medium interaction and cold nuclear matter effects on the jT-dependent jet fragmentation functions in p + Pb collisions were observed. We found the jT-dependent jet fragmentation functions are dominated by the quark coalescence contribution for the new hadronization mechanism, which can be decomposed into narrow and wide parts. The root mean square value of the wide part depends on the jet radius R and jet transverse momentum pT, jet, which is sensitive to different hadronization mechanisms and their components. Therefore, the jT-dependent jet fragmentation functions are proposed as a sensitive probe to study the non-perturbative hadronization effect of jets in small colliding systems. [Duan, Xiang-Pan; Ma, Guo-Liang] Fudan Univ, Inst Modern Phys, Key Lab Nucl Phys & Ion beam Applicat MOE, Shanghai 200433, Peoples R China; [Duan, Xiang-Pan; Ma, Guo-Liang] NSFC, Shanghai Res Ctr Theoret Nucl Phys, Shanghai 200438, Peoples R China; [Duan, Xiang-Pan; Ma, Guo-Liang] Fudan Univ, Shanghai 200438, Peoples R China; [Zhao, Wenbin] Wayne State Univ, Dept Phys & Astron, Detroit, MI 48201 USA Fudan University; Chinese Academy of Sciences; Fudan University; Wayne State University Ma, GL (corresponding author), Fudan Univ, Inst Modern Phys, Key Lab Nucl Phys & Ion beam Applicat MOE, Shanghai 200433, Peoples R China.; Ma, GL (corresponding author), NSFC, Shanghai Res Ctr Theoret Nucl Phys, Shanghai 200438, Peoples R China.; Ma, GL (corresponding author), Fudan Univ, Shanghai 200438, Peoples R China. zhaowenb@pku.edu.cn; glma@fudan.edu.cn Ma, Guo-Liang/0000-0002-7002-8442 National Natural Science Foundation of China [12147101, 11890714, 11835002, 11961131011, 11421505]; National Key Research and Development Program of China [2022YFA1604900]; Strategic Priority Research Program of Chinese Academy of Sciences [XDB34030000]; Guangdong Major Project of Basic and Applied Basic Research [2020B0301030008]; National Science Foundation (NSF) [ACI-2004571] National Natural Science Foundation of China(National Natural Science Foundation of China (NSFC)); National Key Research and Development Program of China; Strategic Priority Research Program of Chinese Academy of Sciences(Chinese Academy of Sciences); Guangdong Major Project of Basic and Applied Basic Research; National Science Foundation (NSF)(National Science Foundation (NSF)) AcknowledgementsX.-P.D. and G.-L.M. are supported by the National Natural Science Foundation of China under Grants Nos. 12147101, 11890714, 11835002, 11961131011, 11421505, the National Key Research and Development Program of China under Contract No. 2022YFA1604900, the Strategic Priority Research Program of Chinese Academy of Sciences under Grant No. XDB34030000, and the Guangdong Major Project of Basic and Applied Basic Research under Grant No. 2020B0301030008. W. Z. is supported by the National Science Foundation (NSF) under Grant No. ACI-2004571 within the framework of the XSCAPE project of the JETSCAPE collaboration. 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J Eapen, D; Mbango, C; Daniels, G; Joseph, NM; Mary, A; Mathews, N; Carr, KK; Wells, C; Suriaga, A; Saint Fleur, A Eapen, Doncy; Mbango, Catherine; Daniels, Glenda; Mathew Joseph, Nitha; Mary, Annapoorna; Mathews, Nisha; Carr, Kathryn Kravetz; Wells, Cheryl; Suriaga, Armiel; Saint Fleur, Angeline Recommendations to improve maternal health equity among Black women in The South": A position paper from the SNRS minority health research interest & implementation group
