Effectiveness of Bivalent mRNA COVID-19 Vaccines in Preventing COVID-19-Related Thromboembolic Events Among Medicare Enrollees Aged ≥65 Years and Those with End Stage Renal Disease - United States, September 2022-March 2023

被引：0

作者：

Payne, Amanda B. ^{[1
]}

Novosad, Shannon ^{[2
]}

Wiegand, Ryan E. ^{[1
]}

Najdowski, Morgan ^{[1
]}

Gomes, Danica J. ^{[2
]}

Wallace, Megan ^{[1
]}

Kelman, Jeffrey A. ^{[3
]}

Sung, Heng-Ming ^{[4
]}

Zhang, Yue ^{[4
]}

Lufkin, Bradley ^{[4
]}

Chillarige, Yoganand ^{[4
]}

Link-Gelles, Ruth ^{[1
]}

机构：

[1] CDC, Natl Ctr Immunizat & Resp Dis, Coronavirus & Other Resp Viruses Div, Atlanta, GA 30329 USA

[2] CDC, Natl Ctr Emerging & Zoonot Infect Dis, Div Healthcare Qual Promot, Atlanta, GA 30333 USA

[3] Ctr Medicare & Medicaid Serv, Baltimore, MD USA

[4] Acumen LLC, Burlingame, CA USA

来源：

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT | 2024年 / 73卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

COVID-19 has been associated with an increased risk for thromboembolic events, including ischemic stroke, venous thromboembolism, and myocardial infarction. Studies have reported lower rates of COVID-19-related thromboembolic events among persons who received the COVID-19 vaccine compared with persons who did not, but rigorous estimates of vaccine effectiveness (VE) in preventing COVID-19-related thromboembolic events are lacking. This analysis estimated the incremental benefit of receipt of a bivalent mRNA COVID-19 vaccine after receiving an original monovalent COVID-19 vaccine. To estimate VE of a bivalent mRNA COVID-19 dose in preventing thromboembolic events compared with original monovalent COVID-19 vaccine doses only, two retrospective cohort studies were conducted among Medicare fee-for-service enrollees during September 4, 2022-March 4, 2023. Effectiveness of a bivalent COVID-19 vaccine dose against COVID-19-related thromboembolic events compared with that of original vaccine alone was 47% (95% CI = 45%-49%) among Medicare enrollees aged >= 65 years and 51% (95% CI = 39%-60%) among adults aged >= 18 years with end stage renal disease receiving dialysis. VE was similar among Medicare beneficiaries with immunocompromise: 46% (95% CI = 42%-49%) among adults aged >= 65 years and 45% (95% CI = 24%-60%) among those aged >= 18 years with end stage renal disease. To help prevent complications of COVID-19, including thromboembolic events, adults should stay up to date with COVID-19 vaccination.

引用

页码：16 / 23

页数：8

共 50 条

[21] Post-COVID Conditions Among Adult COVID-19 Survivors Aged 18-64 and ≥65 Years - United States, March 2020-November 2021
Bull-Otterson, Lara
Baca, Sarah
Saydah, Sharon
Boehmer, Tegan K.
Adjei, Stacey
Gray, Simone
Harris, Aaron M.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2022, 71 (21): : 713 - 717
[22] Safety Monitoring of Bivalent COVID-19 mRNA Vaccine Booster Doses Among Children Aged 5-11 Years - United States, October 12-January 1, 2023
Hause, Anne M.
Marquez, Paige
Zhang, Bicheng
Su, John R.
Myers, Tanya R.
Gee, Julianne
Panchanathan, Sarada S.
Thompson, Deborah
Shimabukuro, Tom T.
Shay, David K.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2023, 72 (02): : 39 - 43
[23] Differences in COVID-19 Outpatient Antiviral Treatment Among Adults Aged ≥65 Years by Age Group - National Patient-Centered Clinical Research Network, United States, April 2022-September 2023
Quinlan, Claire M.
Shah, Melisa M.
Desantis, Carol E.
Bertumen, J. Bradford
Draper, Christine
Ahmad, Faraz S.
Arnold, Jonathan
Mayer, Kenneth H.
Carton, Thomas W.
Cowell, Lindsay G.
Smith, Samantha
Saydah, Sharon
Jones, Jefferson M.
Patel, Pragna
Hagen, Melissa Briggs
Block, Jason
Koumans, Emily H.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2024, 73 (39): : 876 - 882
[24] Effectiveness of COVID-19 mRNA Vaccination in Preventing COVID-19-Associated Hospitalization Among Adults with Previous SARS-CoV-2 Infection - United States, June 2021-February 2022
Plumb, Ian D.
Feldstein, Leora R.
Barkley, Eric
Posner, Alexander B.
Bregman, Howard S.
Hagen, Melissa Briggs
Gerhart, Jacqueline L.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2022, 71 (15): : 549 - 555
[25] SARS-CoV-2 Epidemiology and COVID-19 mRNA Vaccine Effectiveness Among Infants and Children Aged 6 Months-4 Years - New Vaccine Surveillance Network, United States, July 2022-September 2023
Tannis, Ayzsa
Englund, Janet A.
Perez, Ariana
Harker, Elizabeth J.
Staat, Mary Allen
Schlaudecker, Elizabeth P.
Halasa, Natasha B.
Stewart, Laura S.
Williams, John, V
Michaels, Marian G.
Selvarangan, Rangaraj
Schuster, Jennifer E.
Sahni, Leila C.
Boom, Julie A.
Weinberg, Geoffrey A.
Szilagyi, Peter G.
Clopper, Benjamin R.
Zhou, Yingtao
McMorrow, Meredith L.
Klein, Eileen J.
Moline, Heidi L.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2023, 72 (48): : 1300 - 1306
[26] Effectiveness of Pfizer-BioNTech mRNA Vaccination Against COVID-19 Hospitalization Among Persons Aged 12-18 Years - United States, June-September 2021
Olson, Samantha M.
Newhams, Margaret M.
Halasa, Natasha B.
Price, Ashley M.
Boom, Julie A.
Sahni, Leila C.
Irby, Katherine
Walker, Tracie C.
Schwartz, Stephanie P.
Pannaraj, Pia S.
Maddux, Aline B.
Bradford, Tamara T.
Nofziger, Ryan A.
Boutselis, Benjamin J.
Cullimore, Melissa L.
Mack, Elizabeth H.
Schuster, Jennifer E.
Gertz, Shira J.
Cvijanovich, Natalie Z.
Kong, Michele
Cameron, Melissa A.
Staat, Mary A.
Levy, Emily R.
Chatani, Brandon M.
Chiotos, Kathleen
Zambrano, Laura D.
Campbell, Angela P.
Patel, Manish M.
Randolph, Adrienne G.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2021, 70 (42): : 1483 - 1488
[27] Effectiveness Over Time of a Complete Primary Series of the Original, Monovalent COVID-19 Vaccines Among Adults Aged 18-64 Years in the United States
Layton, J. Bradley
Peetluk, Lauren S.
Lloyd, Patricia C.
Jiao, Yixin
Djibo, Djeneba Audrey
Deng, Jie
Gruber, Joann F.
Ogilvie, Rachel P.
Parambi, Ron J.
Miller, Michael
Song, Jennifer
Weatherby, Lisa B.
Bell, Elizabeth J.
Lo, An-Chi
Hervol, Jessica R.
Wernecke, Michael
Cho, Sylvia
Wong, Hui-Lee
Clarke, Tainya C.
Bui, Christine L.
Stone, Alexandra
Tarazi, Wafa
Deshazo, Jonathan
Forshee, Richard A.
Anderson, Steven A.
Seeger, John D.
Amend, Kandace L.
McMahill-Walraven, Cheryl N.
Chillarige, Yoganand
Yang, Grace W.
Anthony, Mary S.
Shoaibi, Azadeh
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2024, 33 : 54 - 54
[28] The Advisory Committee on Immunization Practices' Recommendation for Use of Moderna COVID-19 Vaccine in Adults Aged ≥ 18 Years and Considerations for Extended Intervals for Administration of Primary Series Doses of mRNA COVID-19 Vaccines - United States, February 2022
Wallace, Megan
Moulia, Danielle
Blain, Amy E.
Ricketts, Erin K.
Minhaj, Faisal S.
Link-Gelles, Ruth
Curran, Kathryn G.
Hadler, Stephen C.
Asif, Amimah
Godfrey, Monica
Hall, Elisha
Fiore, Anthony
Meyer, Sarah
Su, John R.
Weintraub, Eric
Oster, Matthew E.
Shimabukuro, Tom T.
Campos-Outcalt, Doug
Morgan, Rebecca L.
Bell, Beth P.
Brooks, Oliver
Talbot, H. Keipp
Lee, Grace M.
Daley, Matthew F.
Oliver, Sara E.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2022, 71 (11): : 416 - 421
[29] Real-world Effectiveness of mRNA COVID-19 Vaccines Among US Nursing Home Residents Aged ≥65 Years in the Pre-Delta and High Delta Periods
Lu, Yun
Lindaas, Arnstein
Matuska, Kathryn
Izurieta, Hector S.
McEvoy, Rowan
Menis, Mikhail
Shi, Xiangyu
Steele, Whitney R.
Wernecke, Michael
Chillarige, Yoganand
Wong, Hui Lee
Kelman, Jeffrey A.
Forshee, Richard A.
OPEN FORUM INFECTIOUS DISEASES, 2024, 11 (03):
[30] Absolute and Relative Vaccine Effectiveness of Primary and Booster Series of COVID-19 Vaccines (mRNA and Adenovirus Vector) Against COVID-19 Hospitalizations in the United States, December 2021-April 2022 (vol 10, ofac698,2023)
Lewis, Nathaniel M.
Murray, Nancy
Adams, Katherine
Surie, Diya
Gaglani, Manjusha
Ginde, Adit A.
McNeal, Tresa
Ghamande, Shekhar
Douin, David J.
Talbot, H. Keipp
Casey, Jonathan D.
Mohr, Nicholas M.
Zepeski, Anne
Shapiro, Nathan, I
Gibbs, Kevin W.
Files, D. Clark
Hager, David N.
Ali, Harith
Prekker, Matthew E.
Frosch, Anne E.
Exline, Matthew C.
Gong, Michelle N.
Mohamed, Amira
Johnson, Nicholas J.
Srinivasan, Vasisht
Steingrub, Jay S.
Peltan, Ithan D.
Brown, Samuel M.
Martin, Emily T.
Monto, Arnold S.
Lauring, Adam S.
Khan, Akram
Hough, Catherine L.
Busse, Laurence W.
Bender, William
Duggal, Abhijit
Wilson, Jennifer G.
Gordon, Alexandra June
Qadir, Nida
Chang, Steven Y.
Mallow, Christopher
Rivas, Carolina
Babcock, Hilary M.
Kwon, Jennie H.
Chappell, James D.
Halasa, Natasha
Grijalva, Carlos G.
Rice, Todd W.
Stubblefield, William B.
Baughman, Adrienne
OPEN FORUM INFECTIOUS DISEASES, 2023, 10 (05):

← 1 2 3 4 5 →