Pillar[n]MaxQ sensing ensemble: Application to world anti-doping agency banned substances

被引：5
|
作者：
King, David [1 ]
Deng, Chun-Lin [1 ]
Isaacs, Lyle [1 ]
机构：
[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
来源：
TETRAHEDRON | 2023年 / 145卷
基金：
美国国家科学基金会;
关键词：
Pillararene; Sensing ensemble; WADA banned substances; Host-guest chemistry; HIGH-ENERGY WATER; CONSTANTS; SENSORS;
D O I：
10.1016/j.tet.2023.133607
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The molecular recognition properties of two pillar[n]arene sulfates (P[5]AS and P[6]AS) toward a panel of world anti-doping agency banned substances (1-11) were investigated by a combination of isothermal titration calorimetry, 1H NMR spectroscopy, and molecular modelling. Subsequently a sensing ensemble based on indicator displacement was created using the P[5]AS & BULL;lucigenin and P[6]AS & BULL;Hoechst 33258 complexes which allowed differentiation among the analytes with 90% accuracy. The assay was extended to allow the quantitation of pseudoephedrine in simulated urine samples with a limit of quantitation that is 30-fold below the WADA threshold.
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页数：7
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