Pillar[n]MaxQ sensing ensemble: Application to world anti-doping agency banned substances

被引：5
|
作者：
King, David [1 ]
Deng, Chun-Lin [1 ]
Isaacs, Lyle [1 ]
机构：
[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
来源：
TETRAHEDRON | 2023年 / 145卷
基金：
美国国家科学基金会;
关键词：
Pillararene; Sensing ensemble; WADA banned substances; Host-guest chemistry; HIGH-ENERGY WATER; CONSTANTS; SENSORS;
D O I：
10.1016/j.tet.2023.133607
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The molecular recognition properties of two pillar[n]arene sulfates (P[5]AS and P[6]AS) toward a panel of world anti-doping agency banned substances (1-11) were investigated by a combination of isothermal titration calorimetry, 1H NMR spectroscopy, and molecular modelling. Subsequently a sensing ensemble based on indicator displacement was created using the P[5]AS & BULL;lucigenin and P[6]AS & BULL;Hoechst 33258 complexes which allowed differentiation among the analytes with 90% accuracy. The assay was extended to allow the quantitation of pseudoephedrine in simulated urine samples with a limit of quantitation that is 30-fold below the WADA threshold.
引用
收藏
页数：7
相关论文
共 48 条
  • [1] Pseudoephedrine to return to the World Anti-Doping Agency banned list
    不详
    [J]. BIOANALYSIS, 2009, 1 (08) : 1394 - 1394
  • [2] Prevalence of caffeine use in elite athletes following its removal from the World Anti-Doping Agency list of banned substances
    Del Coso, Juan
    Munoz, Gloria
    Munoz-Guerra, Jesus
    [J]. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, 2011, 36 (04) : 555 - 561
  • [3] Is trimetazidine (Vastarel) a doping agent? Proposal for a deletion of the world anti -doping agency list of banned substances
    Kintz, Pascal
    [J]. TOXICOLOGIE ANALYTIQUE ET CLINIQUE, 2020, 32 (04) : 239 - 241
  • [4] Legitimacy driven change at the World Anti-Doping Agency
    Read, Daniel
    Skinner, James
    Lock, Daniel
    Houlihan, Barrie
    [J]. INTERNATIONAL JOURNAL OF SPORT POLICY AND POLITICS, 2019, 11 (02) : 233 - 245
  • [5] Reflections on a recent report of the World Anti-Doping Agency
    Faber, Nicolaas M.
    [J]. ACCREDITATION AND QUALITY ASSURANCE, 2014, 19 (02) : 139 - 139
  • [6] The World Anti-Doping Agency at 20: progress and challenges
    Houlihan, Barrie
    Hanstad, Dag Vidar
    Loland, Sigmund
    Waddington, Ivan
    [J]. INTERNATIONAL JOURNAL OF SPORT POLICY AND POLITICS, 2019, 11 (02) : 193 - 201
  • [7] The World Anti-Doping Agency: The Role of Social Marketing
    O'Reilly, Norm
    Madill, Judith
    [J]. JOURNAL OF NONPROFIT & PUBLIC SECTOR MARKETING, 2007, 17 (1-2) : 1 - 26
  • [8] Reflections on a recent report of the World Anti-Doping Agency
    Nicolaas M. Faber
    [J]. Accreditation and Quality Assurance, 2014, 19 : 139 - 139
  • [9] The List of Prohibited Substances and Methods in Sport: Structure and Review Process by the World Anti-Doping Agency
    Mazzoni, Irene
    Barroso, Osquel
    Rabin, Olivier
    [J]. JOURNAL OF ANALYTICAL TOXICOLOGY, 2011, 35 (09) : 608 - 612
  • [10] Analysis of a challenging subset of world anti-doping agency-banned steroids and antiestrogens by LC-MS-MS
    Borges, Chad R.
    Miller, Nicole
    Shelby, Melinda
    Hansen, Megan
    White, Claudia
    Slawson, Matthew H.
    Monti, Kim
    Crouch, Dennis J.
    [J]. JOURNAL OF ANALYTICAL TOXICOLOGY, 2007, 31 (03) : 125 - 131
12345