Secondary-Type Mutations Do Not Impact the Favorable Outcome of NPM1-Mutated Acute Myeloid Leukemia Patients - Results from a Large Cohort of Intensively Treated Patients

被引：1

作者：

Bill, Marius ^{[1
]}

Eckardt, Jan-Niklas ^{[1
]}

Rausch, Christian ^{[2
]}

Metzeler, Klaus H. ^{[3
]}

Spiekermann, Karsten ^{[4
]}

Stasik, Sebastian ^{[5
]}

Sauer, Tim ^{[6
]}

Scholl, Sebastian ^{[7
]}

Hochhaus, Andreas ^{[8
]}

Crysandt, Martina ^{[9
,10
]}

Bruemmendorf, Tim H. ^{[10
]}

Krug, Utz ^{[11
]}

Woermann, Bernhard ^{[12
]}

Hiddemann, Wolfgang

Goerlich, Dennis ^{[13
]}

Sauerland, Maria Cristina ^{[13
]}

Steffen, Bjoern ^{[14
]}

Einsele, Hermann ^{[15
]}

Neubauer, Andreas ^{[16
]}

Burchert, Andreas ^{[17
]}

Schaefer-Eckart, Kerstin ^{[18
]}

Berdel, Wolfgang E. ^{[19
]}

Schliemann, Christoph ^{[20
]}

Krause, Stefan W. ^{[21
]}

Hanel, Mathias ^{[22
]}

Hanoun, Maher ^{[23
]}

Kaufmann, Martin ^{[24
]}

Fransecky, Lars ^{[25
]}

Braess, Jan ^{[26
]}

Ruhnke, Leo ^{[27
]}

Schetelig, Johannes ^{[28
,29
]}

Middeke, Jan Moritz ^{[1
]}

Serve, Hubert ^{[30
]}

Baldus, Claudia D. ^{[31
]}

Platzbecker, Uwe ^{[32
]}

Mueller-Tidow, Carsten

Bornhaeuser, Martin

Herold, Tobias ^{[33
]}

Thiede, Christian ^{[5
]}

Roellig, Christoph ^{[27
]}

机构：

[1] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Internal Med 1, Dresden, Germany

[2] Ludwig Maximilians Univ Munchen, LMU Univ Hosp, Dept Med 3, Lab Leukemia Diagnost, Munich, Germany

[3] Univ Leipzig, Med Ctr, Dept Hematol Cellular Therapy Hemostaseol & Infec, Leipzig, Germany

[4] Ludwig Maximilians Univ Munchen, LMU Univ Hosp, Dept Med 3, Munich, Germany

[5] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Internal Med 1, Dresden, Germany

[6] Heidelberg Univ Hosp, Heidelberg, Germany

[7] Jena Univ Hosp, Klin Innere Med 2, Jena, Germany

[8] Klin Innere Med II, Dept Hematol & Oncol, Jena, Germany

[9] Univ Hosp RWTH Aachen, Dept Hematol & Oncol, Aachen, Germany

[10] Ctr Integrated Oncol Aachen Bonn Cologne Duesseld, Aachen, Germany

[11] Hosp Leverkusen, Dept Med 3, Leverkusen, Germany

[12] Charite, Dept Hematol Oncol & Tumor Immunol, Berlin, Germany

[13] Univ Munster, Inst Biostat & Clin Res, Munster, Germany

[14] Univ Hosp Frankfurt, Dept Hematol & Oncol, Frankfurt, Germany

[15] Univ Hosp Wurzburg, Dept Internal Med 2, Wurzburg, Germany

[16] Phillips Univ Marburg, Dept Hematol Oncol & Immunol, Marburg, Germany

[17] Univ Klinikum Giessen & Marburg, Hamatol Onkol & Immunol, Marburg, Germany

[18] BMT Unit, Med Clin 2, Nurnberg, Germany

[19] Univ Hosp Muenster, Dept Med Hematol & Oncol A, Munster, Germany

[20] Univ Hosp Muenster, Dept Med Hematol Oncol & Pneumol A, Munster, Germany

[21] Univ Klinikum Erlangen, Erlangen, Germany

[22] Klinikum Chemnitz, Dept Internal Med 3, Chemnitz, Germany

[23] Univ Hosp Essen, Dept Hematol, Essen, Germany

[24] Robert Bosch Krankenhaus, Dept Hematol Oncol & Palliat Care, Stuttgart, Germany

[25] Univ Hosp Schleswig Holstein Campus Kiel, Dept Internal Med Hematol Oncol 2, Kiel, Germany

[26] Hosp Barmherzige Brueder Regensburg, Regensburg, Germany

[27] Univ Hosp Dresden, Dept Internal Med 1, Dresden, Germany

[28] Tech Univ Dresden, Dresden, Germany

[29] DKMS Grp gGmbH, Dresden, Germany

[30] Goethe Univ Hosp Frankfurt, Dept Internal Med Hematol & Oncol 2, Frankfurt, Germany

[31] Univ Hosp Schleswig Holstein, Dept Hematol & Oncol, Campus Kiel, Kiel, Germany

[32] Univ Leipzig, Med Ctr, Leipzig, Germany

[33] Ludwig Maximilians Univ Munchen, LMU Univ Hosp, Dept Med 3, Munich, Germany

来源：

BLOOD | 2023年 / 142卷

关键词：

D O I：

10.1182/blood-2023-186160

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：6

共 50 条

[21] Favorable outcomes for allogeneic hematopoietic cell transplantation in elderly patients with NPM1-mutated and FLT3-ITD-negative acute myeloid leukemia
Ibrahim Aldoss
Ryotaro Nakamura
Dongyun Yang
Amandeep Salhotra
Anthony S. Stein
Vinod Pullarkat
Stephen J. Forman
Guido Marcucci
Bone Marrow Transplantation, 2020, 55 : 473 - 475
[22] Mutational spectrum of de novo NPM1-mutated acute myeloid leukemia patients older than 75 years
Pettersson, Louise
Holmgren, Benjamin
Juliusson, Gunnar
Lazarevic, Vladimir Lj
Ehinger, Mats
LEUKEMIA & LYMPHOMA, 2021, 62 (08) : 1958 - 1966
[23] Monoallelic CEBPA mutations in normal karyotype acute myeloid leukemia: independent favorable prognostic factor within NPM1 mutated patients
Annika Dufour
Friederike Schneider
Eva Hoster
Tobias Benthaus
Bianka Ksienzyk
Stephanie Schneider
Purvi M. Kakadia
Maria-Cristina Sauerland
Wolfgang E. Berdel
Thomas Büchner
Bernhard Wörmann
Jan Braess
Marion Subklewe
Wolfgang Hiddemann
Stefan K. Bohlander
Karsten Spiekermann
Annals of Hematology, 2012, 91 : 1051 - 1063
[24] Monoallelic CEBPA mutations in normal karyotype acute myeloid leukemia: independent favorable prognostic factor within NPM1 mutated patients
Dufour, Annika
Schneider, Friederike
Hoster, Eva
Benthaus, Tobias
Ksienzyk, Bianka
Schneider, Stephanie
Kakadia, Purvi M.
Sauerland, Maria-Cristina
Berdel, Wolfgang E.
Buechner, Thomas
Woermann, Bernhard
Braess, Jan
Subklewe, Marion
Hiddemann, Wolfgang
Bohlander, Stefan K.
Spiekermann, Karsten
ANNALS OF HEMATOLOGY, 2012, 91 (07) : 1051 - 1063
[25] Sequential next generation sequencing analysis in homogeneously treated low risk NPM1-mutated acute myeloid leukemia with an adverse clinical outcome
Rossi, Marianna
Nizzoli, Maria Elena
Galli, Anna
Roncoroni, Elisa
Zibellini, Silvia
Merati, Gabriele
Rizzo, Ettore
Rocca, Barbara
Pietra, Daniela
Picone, Cristina
Brociner, Marco
Tobar Cabrera, Claudia Patricia
Gelli, Eleonora
Santacroce, Eugenio
Arcaini, Luca
Zappasodi, Patrizia
AMERICAN JOURNAL OF HEMATOLOGY, 2022, 97 (04) : E135 - E138
[26] THE IMPACT OF FLT3 MUTATIONS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA: TYPE, SIZE AND INTERACTION WITH NPM1 MUTATIONS
Tosic, N.
Colovic, N.
Colovic, M.
Zukic, B.
Pavlovic, S.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 456 - 456
[27] Multi lineage dysplasia as assessed by immunophenotype has no impact on clinical-biological features and outcome of NPM1-mutated acute myeloid leukemia
Mannelli, Francesco
Ponziani, Vanessa
Bonetti, Maria Ida
Bencini, Sara
Cutini, Ilaria
Gianfaldoni, Giacomo
Scappini, Barbara
Pancani, Fabiana
Rondelli, Tommaso
Benelli, Matteo
Caporale, Roberto
Gelli, Anna Maria Grazia
Peruzzi, Benedetta
Longo, Giovanni
Bosi, Alberto
EXPERIMENTAL HEMATOLOGY, 2015, 43 (10) : 869 - 879
[28] Prognostic Impact of NPM1 Mutations in Serbian Adult Patients with Acute Myeloid Leukemia
Kuzmanovic, Milos
Tosic, Natasa
Colovic, Natasa
Karan-Djurasevic, Teodora
Spasovski, Vesna
Radmilovic, Milena
Nikcevic, Gordana
Suvajdzic-Vukovic, Nada
Tomin, Dragica
Vidovic, Ana
Virijevic, Marijana
Pavlovic, Sonja
Colovic, Milica
ACTA HAEMATOLOGICA, 2012, 128 (04) : 203 - 212
[29] Co-mutation landscape and its prognostic impact on newly diagnosed adult patients with NPM1-mutated de novo acute myeloid leukemia
Yao, Yiyi
Zhou, Yile
Zhuo, Nanfang
Xie, Wanzhuo
Meng, Haitao
Lou, Yinjun
Mao, Liping
Tong, Hongyan
Qian, Jiejing
Yang, Min
Yu, Wenjuan
Zhou, De
Jin, Jie
Wang, Huafeng
BLOOD CANCER JOURNAL, 2024, 14 (01):
[30] DISTINCT CLINICO-BIOLOGICAL FEATURES IN NPM1-MUTATED ACUTE MYELOID LEUKEMIA PATIENTS FOLLOWING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION
Yuan, Xiaolin
Yibo, W.
Lai, Xiaoyu
Liu, Lizhen
Shi, Jimin
Zheng, Weiyan
Yu, Jian
Zhao, Yanmin
Sun, Jie
Cai, Zhen
Haung, He
Luo, Yi
BONE MARROW TRANSPLANTATION, 2024, 59 : 356 - 357

← 1 2 3 4 5 →