Toxin exposure and HLA alleles determine serum antibody binding to toxic shock syndrome toxin 1 (TSST-1) of Staphylococcus aureus

被引：2

作者：

Weiss, Stefan ^{[1
,2
]}

Holtfreter, Silva ^{[3
]}

Meyer, Tanja C. ^{[1
]}

Schmiedeke, Frieder ^{[3
]}

Cammann, Clemens ^{[4
]}

Doerr, Marcus ^{[2
,5
]}

Felix, Stephan B. ^{[2
,5
]}

Grabe, Hans J. ^{[6
]}

Homuth, Georg ^{[1
]}

Kohler, Christian ^{[4
]}

Mahncke, Cedric ^{[4
]}

Michalik, Stephan ^{[1
]}

Nauck, Matthias ^{[2
,7
]}

Friedrich, Nele ^{[2
,7
]}

Samietz, Stefanie ^{[8
]}

Voelzke, Henry ^{[2
,9
]}

Voelker, Uwe ^{[1
,2
]}

Broeker, Barbara M. ^{[3
]}

机构：

[1] Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany

[2] German Ctr Cardiovasc Res DZHK, Partner Site Greifswald, Greifswald, Germany

[3] Univ Med Greifswald, Inst Immunol, Greifswald, Germany

[4] Univ Med Greifswald, Friedrich Loeffler Inst Med Microbiol, Greifswald, Germany

[5] Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany

[6] Univ Med Greifswald, Dept Psychatry & Psychotherapy, Greifswald, Germany

[7] Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany

[8] Univ Med Greifswald, Dept Prosthet Dent Gerodontol & Biomat, Greifswald, Germany

[9] Univ Med Greifswald, Inst Community Med, Greifswald, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

Staphylococcus aureus; toxic shock syndrome; TSST-1; superantigen; GWA; HLA; MHC; antibody; BACTERIAL SUPERANTIGENS; IGG4; PRODUCTION; REFERENCE PANEL; NASAL CARRIERS; ENTEROTOXIN-F; PREVALENCE; POPULATION; RESPONSES; COLONIZATION; ASSOCIATION;

D O I：

10.3389/fimmu.2023.1229562

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus. A well-known risk factor is the lack of neutralizing antibodies. To identify determinants of the anti-TSST-1 antibody response, we examined 976 participants of the German population-based epidemiological Study of Health in Pomerania (SHIP-TREND-0). We measured anti-TSST-1 antibody levels, analyzed the colonization with TSST-1-encoding S. aureus strains, and performed a genome-wide association analysis of genetic risk factors. TSST-1-specific serum IgG levels varied over a range of 4.2 logs and were elevated by a factor of 12.3 upon nasal colonization with TSST-1-encoding S. aureus. Moreover, the anti-TSST-1 antibody levels were strongly associated with HLA class II gene loci. HLA-DRB1*03:01 and HLA-DQB1*02:01 were positively, and HLA-DRB1*01:01 as well as HLA-DQB1*05:01 negatively associated with the anti-TSST-1 antibody levels. Thus, both toxin exposure and HLA alleles affect the human antibody response to TSST-1.

引用

页数：14

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