Synthesis, molecular docking and CNS activity of 5,5-diphenylimidazolidine-2,4-dione derivatives

被引：0

作者：

Verma, Shweta ^{[1
]}

Rani, Sonam ^{[1
]}

机构：

[1] IFTM Univ, Fac Pharm, Moradabad 244001, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY | 2023年 / 62卷 / 11期

关键词：

Phenytoin; Parameters; CNS activity; Blood brain barrier; Log P; ELEVATED PLUS-MAZE; ANTICONVULSANT;

D O I：

10.56042/ijc.v62i11.1723

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The new Phenytoin derivatives have been synthesized, characterized, and compared for CNS activity. The synthesis was carried out in three steps. Firstly, the chloroacetylation of the 5,5-diphenyl hydantoin is carried out and then various substituted phenols are added into it and have been evaluated for anti-anxiety activity, muscle relaxant activity and anticonvulsant activity by using different models. The number of parameters have been optimized which reveal that the compound containing chloro group such as C3 and C6 show imperative potential when compared with the standard drug Diazepam. The newly synthesised compounds have the probability to be optimized further to engender new scaffolds to treat various CNS disorders.

引用

页码：1151 / 1161

页数：11

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