Bioorthogonal Photoclick 1,3-Dipolar Cycloaddition Reaction on Protein - A Review Study

被引：0
|
作者：
Mandal, Pritha [1 ]
机构：
[1] Krishnagar Govt Coll, Dept Chem, Krishnagar 741101, West Bengal, India
来源：
CURRENT ORGANIC CHEMISTRY | 2023年 / 27卷 / 04期
关键词：
Photoclick reaction; bioorthogonal reaction; protein labeling; dipolar cycloaddition; tetrazole; SPAAC; AZIDE-ALKYNE CYCLOADDITION; CLICK CHEMISTRY; SELECTIVE MODIFICATION; NITRILE IMINE; IN-VIVO; ALKENE; LIGHT; LIGATION; FUNCTIONALIZATION; MECHANISM;
D O I：
10.2174/1385272827666230417104739
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Click reactions have gained enormous popularity among chemists for their ambient reaction parameters and wide application in various frontier research fields. Photo-initiated click reactions add another dimension of spatiotemporal control which ensures fruitful bioorthogonal reaction. Several cycloaddition reactions, enlisted in the category of 'photo click' reactions due to the fast kinetics and ambient reaction conditions, are widely utilized by scientists for bioorthogonal conjugation. In this review, various types of 1,3-dipolar cycloaddition reactions and their applications in the field of protein bioconjugation are discussed.
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页码：297 / 307
页数：11
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